The inhibition of NFкB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity
A Ahmadi, H Niknahad, H Li, A Mobasheri… - Toxicology Letters, 2021 - Elsevier
The cholestatic liver injury could occur in response to a variety of diseases or xenobiotics.
Although cholestasis primarily affects liver function, it has been well-known that other organs …
Although cholestasis primarily affects liver function, it has been well-known that other organs …
Drug‐induced organ injury in coronavirus disease 2019 pharmacotherapy: Mechanisms and challenges in differential diagnosis and potential protective strategies
MM Ommati, A Mobasheri… - Journal of Biochemical …, 2021 - Wiley Online Library
The world is currently facing an unprecedented pandemic caused by a newly recognized
and highly pathogenic coronavirus disease 2019 (COVID‐19; induced by SARS‐CoV‐2 …
and highly pathogenic coronavirus disease 2019 (COVID‐19; induced by SARS‐CoV‐2 …
Nitric oxide releasing nanofibrous Fmoc-dipeptide hydrogels for amelioration of renal ischemia/reperfusion injury
Renal ischemia/reperfusion (I/R) injury is responsible for significant mortality and morbidity
during renal procedures. Nitric oxide (NO) deficiency is known to play a crucial role in renal …
during renal procedures. Nitric oxide (NO) deficiency is known to play a crucial role in renal …
The role of mitochondrial impairment and oxidative stress in the pathogenesis of lithium-induced reproductive toxicity in male mice
Lithium (Li+) is prescribed against a wide range of neurological disorders. Besides its
excellent therapeutic properties, there are several adverse effects associated with Li+. The …
excellent therapeutic properties, there are several adverse effects associated with Li+. The …
Taurine improves sperm mitochondrial indices, blunts oxidative stress parameters, and enhances steroidogenesis and kinematics of sperm in lead-exposed mice
MM Ommati, S Sabouri, S Retana-Marquez… - Reproductive …, 2023 - Springer
Lead (Pb) is a highly toxic heavy metal. Pb exposure could adversely affect many organs,
including the male reproductive system. Oxidative stress and mitochondrial impairment play …
including the male reproductive system. Oxidative stress and mitochondrial impairment play …
Taurine mitigates cirrhosis-associated heart injury through mitochondrial-dependent and antioxidative mechanisms
K Mousavi, H Niknahad, A Ghalamfarsa… - Clinical and …, 2020 - termedia.pl
Cirrhosis-induced heart injury and cardiomyopathy is a serious consequence of this
disease. It has been shown that bile duct ligated (BDL) animals could serve as an …
disease. It has been shown that bile duct ligated (BDL) animals could serve as an …
Agmatine alleviates hepatic and renal injury in a rat model of obstructive jaundice
Background The cholestatic liver disease could develop in association with a wide range of
etiologies. The liver is the most affected organ by cholestasis. It has also been found that the …
etiologies. The liver is the most affected organ by cholestasis. It has also been found that the …
Skeletal muscle mitochondrial impairment in cirrhosis-induced sarcopenia
Cirrhosis-associated muscle mass loss or sarcopenia is a common complication (17-30%
prevalence) in cirrhotic patients. However, the pathogenesis of this complication is poorly …
prevalence) in cirrhotic patients. However, the pathogenesis of this complication is poorly …
In silico prediction of mitochondrial toxicity of chemicals using machine learning methods
P Zhao, Y Peng, X Xu, Z Wang, Z Wu… - Journal of Applied …, 2021 - Wiley Online Library
Mitochondria are important organelles in human cells, providing more than 95% of the
energy. However, some drugs and environmental chemicals could induce mitochondrial …
energy. However, some drugs and environmental chemicals could induce mitochondrial …
Cellular and mitochondrial taurine depletion in bile duct ligated rats: a justification for taurine supplementation in cholestasis/cirrhosis
Taurine (TAU) is a free amino acid abundant in the human body. Various physiological roles
have been attributed to TAU. At the subcellular level, mitochondria are the primary targets for …
have been attributed to TAU. At the subcellular level, mitochondria are the primary targets for …