Understanding the nebulisation of antibiotics: the key role of lung microdialysis studies
Background Nebulisation of antibiotics is a promising treatment for ventilator-associated
pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic …
pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic …
Safety and effectiveness of fifth generation cephalosporins for the treatment of methicillin-resistant staphylococcus aureus bloodstream infections: a narrative review …
DF Bavaro, A Belati, L Bussini, V Cento… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream
infection (BSI) is a major issue in healthcare, since it is often associated with endocarditis or …
infection (BSI) is a major issue in healthcare, since it is often associated with endocarditis or …
Antimicrobial drug penetration is enhanced by lung tissue inflammation and injury
J Geilen, M Kainz, B Zapletal, A Naka… - American journal of …, 2024 - atsjournals.org
Rationale: Pneumonia is a frequent and feared complication in intubated critically ill
patients. Tissue concentrations of antimicrobial drugs need to be sufficiently high to treat the …
patients. Tissue concentrations of antimicrobial drugs need to be sufficiently high to treat the …
Physiologically based pharmacokinetic modelling to inform combination dosing regimens of ceftaroline and daptomycin in special populations
FS Martins, JES Martins, P Severino… - British Journal of …, 2023 - Wiley Online Library
Aims The combination of daptomycin and ceftaroline used as salvage therapy is associated
with higher survival and decreased clinical failure in complicated methicillin‐resistant …
with higher survival and decreased clinical failure in complicated methicillin‐resistant …
Targeted Therapy of Severe Infections Caused by Staphylococcus aureus in Critically Ill Adult Patients: A Multidisciplinary Proposal of Therapeutic Algorithms Based …
(1) Introduction: To develop evidence-based algorithms for targeted antibiotic therapy of
infections caused by Staphylococcus aureus in critically ill adult patients.(2) Methods: A …
infections caused by Staphylococcus aureus in critically ill adult patients.(2) Methods: A …