Targeting ferroptosis opens new avenues for the development of novel therapeutics

S Sun, J Shen, J Jiang, F Wang, J Min - Signal transduction and …, 2023 - nature.com
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics,
including altered iron homeostasis, reduced defense against oxidative stress, and abnormal …

Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney

H Bayır, SJ Dixon, YY Tyurina, JA Kellum… - Nature Reviews …, 2023 - nature.com
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

Ferroptosis: past, present and future

J Li, F Cao, H Yin, Z Huang, Z Lin, N Mao, B Sun… - Cell death & …, 2020 - nature.com
Ferroptosis is a new type of cell death that was discovered in recent years and is usually
accompanied by a large amount of iron accumulation and lipid peroxidation during the cell …

Renal clearable ultrasmall single-crystal Fe nanoparticles for highly selective and effective ferroptosis therapy and immunotherapy

H Liang, X Wu, G Zhao, K Feng, K Ni… - Journal of the American …, 2021 - ACS Publications
Iron-based nanoparticles have attracted much attention because of their ability to induce
ferroptosis via a catalyzing Fenton reaction and to further potentiate immunotherapy …

Ferroptosis and its potential role in the physiopathology of Parkinson's Disease

L Mahoney-Sánchez, H Bouchaoui, S Ayton… - Progress in …, 2021 - Elsevier
Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Hydropersulfides inhibit lipid peroxidation and protect cells from ferroptosis

Z Wu, VS Khodade, JPR Chauvin… - Journal of the …, 2022 - ACS Publications
Hydropersulfides (RSSH) are believed to serve important roles in vivo, including as
scavengers of damaging oxidants and electrophiles. The α-effect makes RSSH not only …

Ferroptosis is a type of autophagy-dependent cell death

B Zhou, J Liu, R Kang, DJ Klionsky, G Kroemer… - Seminars in cancer …, 2020 - Elsevier
Macroautophagy (hereafter referred to as autophagy) involves an intracellular degradation
and recycling system that, in a context-dependent manner, can either promote cell survival …

Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke

I Alim, JT Caulfield, Y Chen, V Swarup, DH Geschwind… - Cell, 2019 - cell.com
Ferroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress
in cancer, heat stress in plants, and hemorrhagic stroke. A homeostatic transcriptional …

The application of ferroptosis in diseases

Y Qiu, Y Cao, W Cao, Y Jia, N Lu - Pharmacological Research, 2020 - Elsevier
Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-
dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron …

NAC alleviative ferroptosis in diabetic nephropathy via maintaining mitochondrial redox homeostasis through activating SIRT3-SOD2/Gpx4 pathway

Q Li, J Liao, W Chen, K Zhang, H Li, F Ma… - Free Radical Biology …, 2022 - Elsevier
Diabetic nephropathy (DN) is known as a major microvascular complication in type 1
diabetes. The effect of insulin treatment alone on controlling blood glucose is unsatisfactory …