Epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy and has a unique
metastatic route using ascites, known as the transcoelomic root. However, studies on ascites …

Ovarian cancer (OC) is a disease of major concern with a survival rate of about 40% at five
years. This is attributed to the lack of visible and reliable symptoms during the onset of the …

Peritoneal metastases are the leading cause of morbidity and mortality in ovarian cancer.
Cancer cells float in peritoneal fluid, named ascites, together with a definitely higher number …

An early fundamental step in ovarian cancer progression is the dissemination of cancer cells
through liquid environments, one of them being cancer ascites accumulated in the …

Ovarian cancer ascites fluid contains matrix proteins that can impact tumor growth via
integrin receptor binding. In human ovarian tumor tissue arrays, we find that activation of the …

Glioblastoma multiform (GBM) is the most common and most aggressive primary brain
tumor. The fibronectin receptor, α5 integrin is a pertinent novel therapeutic target. Despite …

At least one-third of patients with epithelial ovarian cancer (OC) present ascites at diagnosis
and almost all have ascites at recurrence. The presence of ascites, which acts as a dynamic …

Epithelial to mesenchymal transition (EMT) is highly plastic with a programme where cells
lose adhesion and become more motile. EMT heterogeneity is one of the factors for disease …

Ovarian cancer displays the highest mortality rate among all types of gynecological cancer
worldwide. The survival of patients with ovarian cancer remains poor due to poor responses …

Background Conventional proteomic approaches have thus far been unable to identify novel
serum biomarkers for ovarian cancer that are more sensitive and specific than the current …