Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases
S Wang, B Liang, W Wang, L Li, N Feng… - Signal transduction and …, 2023 - nature.com
Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …
challenges to public health security and the global economy. The development and …
[HTML][HTML] The “original antigenic sin” and its relevance for SARS-CoV-2 (COVID-19) vaccination
GT Rijkers, FJ van Overveld - Clinical Immunology Communications, 2021 - Elsevier
Imprinting of the specific molecular image of a given protein antigen into immunological
memory is one of the hallmarks of immunity. A later contact with a related, but different …
memory is one of the hallmarks of immunity. A later contact with a related, but different …
Low-dose self-amplifying mRNA COVID-19 vaccine drives strong protective immunity in non-human primates against SARS-CoV-2 infection
AR Rappaport, SJ Hong, CD Scallan, L Gitlin… - Nature …, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic continues to spread globally,
highlighting the urgent need for safe and effective vaccines that could be rapidly mobilized …
highlighting the urgent need for safe and effective vaccines that could be rapidly mobilized …
Syrian hamster convalescence from prototype SARS-CoV-2 confers measurable protection against the attenuated disease caused by the Omicron variant
The mutation profile of the SARS-CoV-2 Omicron (lineage BA. 1) variant posed a concern for
naturally acquired and vaccine-induced immunity. We investigated the ability of prior …
naturally acquired and vaccine-induced immunity. We investigated the ability of prior …
Influence of aerosol delivered BCG vaccination on immunological and disease parameters following SARS-CoV-2 challenge in rhesus macaques
AD White, L Sibley, C Sarfas, AL Morrison… - Frontiers in …, 2022 - frontiersin.org
The tuberculosis vaccine, Bacille Calmette-Guerin (BCG), also affords protection against
non-tuberculous diseases attributable to heterologous immune mechanisms such as trained …
non-tuberculous diseases attributable to heterologous immune mechanisms such as trained …
Animal models for studying coronavirus infections and developing antiviral agents and vaccines
In addition to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East
respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly …
respiratory syndrome coronavirus (MERS-CoV), SARS-CoV-2 has become the third deadly …
Convalescence from prototype SARS-CoV-2 protects Syrian hamsters from disease caused by the Omicron variant
The mutation profile of the SARS-CoV-2 Omicron variant poses a concern for naturally
acquired and vaccine-induced immunity. We investigated the ability of prior infection with an …
acquired and vaccine-induced immunity. We investigated the ability of prior infection with an …
COVID-19 animal models and vaccines: current landscape and future prospects
S Wang, L Li, F Yan, Y Gao, S Yang, X Xia - Vaccines, 2021 - mdpi.com
The worldwide pandemic of coronavirus disease 2019 (COVID-19) has become an
unprecedented challenge to global public health. With the intensification of the COVID-19 …
unprecedented challenge to global public health. With the intensification of the COVID-19 …
Production of recombinant replication-defective lentiviruses bearing the SARS-CoV or SARS-CoV-2 attachment spike glycoprotein and their application in receptor …
N Thakur, G Gallo, AME Elreafey, D Bailey - Bio-protocol, 2021 - bio-protocol.org
For enveloped viruses, such as SARS-CoV-2, transmission relies on the binding of viral
glycoproteins to cellular receptors. Conventionally, this process is recapitulated in the lab by …
glycoproteins to cellular receptors. Conventionally, this process is recapitulated in the lab by …
[HTML][HTML] Detection and quantification of antibody to SARS CoV 2 receptor binding domain provides enhanced sensitivity, specificity and utility
C Rosadas, M Khan, E Parker, F Marchesin… - Journal of Virological …, 2022 - Elsevier
Accurate and sensitive detection of antibody to SARS-CoV-2 remains an essential
component of the pandemic response. Measuring antibody that predicts neutralising activity …
component of the pandemic response. Measuring antibody that predicts neutralising activity …