Exploring the inhibitory potential of Nigella sativa against dengue virus NS2B/NS3 protease and NS5 polymerase using computational approaches

M Mukhtar, HA Khan - RSC advances, 2023 - pubs.rsc.org
Dengue fever, a highly infectious and rapidly spreading vector borne illness, is classified as
a Neglected Tropical Disease (NTD) by WHO because they generally afflict the world's poor …

Effect of “magic chlorine” in drug discovery: an in silico approach

S Joshi, R Srivastava - RSC advances, 2023 - pubs.rsc.org
The chlorine atom plays a vital role in drug design, yet the benefits of chlorine in 250 FDA-
approved chlorine-containing drugs have not been studied properly. To see the “magic …

New Insights into Colorectal Cancer through the Lens of Precision Oncology and Personalized Medicine: Multi-Omics Helps Aging of Predisposed People

A Bayat, A Sharafshah, F Sefat… - Current Aging …, 2024 - benthamdirect.com
Background Recently, there has been a significant evolution in our understanding of the
molecular pathways causing the genesis and progression of cancer via the inter-individual …

Network Analysis and Experimental Verification of the Mechanisms of Hydroxysafflor Yellow A in Ischemic Stroke Following Atherosclerosis

X Han, H Zhou, J Yin, J Zhu, J Yang, H Wan - Molecules, 2023 - mdpi.com
Hydroxysafflor yellow A (HSYA) is derived from Carthamus tinctorius L.(Honghua in
Chinese) and is used to treat cardiovascular and cerebrovascular disease. However, the …

Synthesis, characterization and antioxidant screening of a 1, 10-phenanthroline-based tetraza-macrocyclic ligand and its nickel complex with therapeutic potential and …

EC Ohaekenyem, I Onyido - Pure and Applied Chemistry, 2024 - degruyter.com
In this study, we present a synthetic route for the preparation of a novel 1, 10-phenanthroline-
based tetraza-macrocyclic ligand, 5, 12, 25, 28-tetraazaheptacyclo [14.8. 4.2 ⁴, ⁷. 210, 13.0 …

Physicochemical properties and biological efficacy of 30 DYRK2 Inhibitors for the treatment of prostate cancer

S Joshi, R Srivastava - Vietnam Journal of Chemistry, 2024 - Wiley Online Library
Prostate cancer is the most common cancer among men which has major diagnosis in the
United States in 2017. Among DYRK class II members, dual specificity tyrosine …

Biological Efficacy of 40 Noncovalent SARS-CoV-2 Main Protease Inhibitors: A Computational Study

S Joshi, R Srivastava - Iranian Journal of Science, 2024 - Springer
The COVID-19 crisis caused by Severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has prompted the world to accelerate many drugs and vaccines for emergency use …