Bioreactor systems for bone tissue engineering
J Rauh, F Milan, KP Günther… - Tissue Engineering Part B …, 2011 - liebertpub.com
Bone graft material is often required for the treatment of osseous defects. However, due to
limitations and risks associated with autologous as well as allogenic bone grafting …
limitations and risks associated with autologous as well as allogenic bone grafting …
[HTML][HTML] Gap junctions and hemichannels in signal transmission, function and development of bone
N Batra, R Kar, JX Jiang - Biochimica et Biophysica Acta (BBA) …, 2012 - Elsevier
Gap junctional intercellular communication (GJIC) mediated by connexins, in particular
connexin 43 (Cx43), plays important roles in regulating signal transmission among different …
connexin 43 (Cx43), plays important roles in regulating signal transmission among different …
Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function
JH Kim, I Kim, YJ Seol, IK Ko, JJ Yoo, A Atala… - Nature …, 2020 - nature.com
A bioengineered skeletal muscle construct that mimics structural and functional
characteristics of native skeletal muscle is a promising therapeutic option to treat extensive …
characteristics of native skeletal muscle is a promising therapeutic option to treat extensive …
Control of bone matrix properties by osteocytes
Osteocytes make up 90–95% of the cellular content of bone and form a rich dendritic
network with a vastly greater surface area than either osteoblasts or osteoclasts. Osteocytes …
network with a vastly greater surface area than either osteoblasts or osteoclasts. Osteocytes …
Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs
It is unclear that how subcellular organelles respond to external mechanical stimuli. Here,
we investigated the molecular mechanisms by which mechanical force regulates Ca2+ …
we investigated the molecular mechanisms by which mechanical force regulates Ca2+ …
Nitric oxide signaling in mechanical adaptation of bone
One of the most serious healthcare problems in the world is bone loss and fractures due to a
lack of physical activity in elderly people as well as in bedridden patients or otherwise …
lack of physical activity in elderly people as well as in bedridden patients or otherwise …
Synchrotron X-ray phase nano-tomography-based analysis of the lacunar–canalicular network morphology and its relation to the strains experienced by osteocytes in …
Osteocytes are hypothesized to regulate bone remodeling guided by both biological and
mechanical stimuli. Morphology of the lacunar–canalicular network of osteocytes has been …
mechanical stimuli. Morphology of the lacunar–canalicular network of osteocytes has been …
Bone cell mechanosensation of fluid flow stimulation: a fluid–structure interaction model characterising the role integrin attachments and primary cilia
Load-induced fluid flow acts as an important biophysical signal for bone cell
mechanotransduction in vivo, where the mechanical environment is thought to be monitored …
mechanotransduction in vivo, where the mechanical environment is thought to be monitored …
Bioreactor design towards generation of relevant engineered tissues: focus on clinical translation
A Ravichandran, Y Liu, SH Teoh - Journal of tissue engineering …, 2018 - Wiley Online Library
In tissue engineering and regenerative medicine, studies that utilize 3D scaffolds for
generating voluminous tissues are mostly confined in the realm of in vitro research and …
generating voluminous tissues are mostly confined in the realm of in vitro research and …
Bone morphology allows estimation of loading history in a murine model of bone adaptation
P Christen, B van Rietbergen, FM Lambers… - … and Modeling in …, 2012 - Springer
Bone adapts its morphology (density/micro-architecture) in response to the local loading
conditions in such a way that a uniform tissue loading is achieved ('Wolff's law'). This …
conditions in such a way that a uniform tissue loading is achieved ('Wolff's law'). This …