[HTML][HTML] Reactive oxygen species, oxidative stress, glaucoma and hyperbaric oxygen therapy

C McMonnies - Journal of optometry, 2018 - Elsevier
This review examines the role of oxidative stress in damage to cells of the trabecular
meshwork and associated impaired aqueous drainage as well as damage to retinal …

Microgravity-induced fluid shift and ophthalmic changes

ES Nelson, L Mulugeta, JG Myers - Life, 2014 - mdpi.com
Although changes to visual acuity in spaceflight have been observed in some astronauts
since the early days of the space program, the impact to the crew was considered minor …

Retinal microvascular network and microcirculation assessments in high myopia

M Li, Y Yang, H Jiang, G Gregori, L Roisman… - American journal of …, 2017 - Elsevier
Purpose To investigate the changes of the retinal microvascular network and
microcirculation in high myopia. Design A cross-sectional, matched, comparative clinical …

[HTML][HTML] Intraocular pressure, blood pressure, and retinal blood flow autoregulation: a mathematical model to clarify their relationship and clinical relevance

G Guidoboni, A Harris, S Cassani… - … & visual science, 2014 - jov.arvojournals.org
Purpose.: This study investigates the relationship between intraocular pressure (IOP) and
retinal hemodynamics and predicts how arterial blood pressure (BP) and blood flow …

Autoregulation and neurovascular coupling in the optic nerve head

D Prada, A Harris, G Guidoboni, B Siesky… - survey of …, 2016 - Elsevier
Impairments of autoregulation and neurovascular coupling in the optic nerve head play a
critical role in ocular pathologies, especially glaucomatous optic neuropathy. We critically …

Ocular blood flow as a clinical observation: Value, limitations and data analysis

A Harris, G Guidoboni, B Siesky, S Mathew… - Progress in retinal and …, 2020 - Elsevier
Alterations in ocular blood flow have been identified as important risk factors for the onset
and progression of numerous diseases of the eye. In particular, several population-based …

Neurodegenerative disorders of the eye and of the brain: a perspective on their fluid-dynamical connections and the potential of mechanism-driven modeling

G Guidoboni, R Sacco, M Szopos, L Sala… - Frontiers in …, 2020 - frontiersin.org
Neurodegenerative disorders (NDD) such as Alzheimer's and Parkinson's diseases are
significant causes of morbidity and mortality worldwide. The pathophysiology of NDD is still …

Elevated intraocular pressure causes abnormal reactivity of mouse retinal arterioles

A Gericke, C Mann, JK Zadeh… - Oxidative medicine …, 2019 - Wiley Online Library
Objective. Glaucoma is a leading cause of severe visual impairment and blindness.
Although high intraocular pressure (IOP) is an established risk factor for the disease, the role …

A poroelastic model for the perfusion of the lamina cribrosa in the optic nerve head

P Causin, G Guidoboni, A Harris, D Prada… - Mathematical …, 2014 - Elsevier
In this work we present a mathematical model for the coupling between biomechanics and
hemodynamics in the lamina cribrosa, a thin porous tissue at the base of the optic nerve …

Advances in understanding glaucoma pathogenesis: a multifaceted molecular approach for clinician scientists

E Ekici, S Moghimi - Molecular Aspects of Medicine, 2023 - Elsevier
Glaucoma, a leading cause of irreversible blindness worldwide, is a spectrum of
neurodegenerative diseases characterized by the gradual deterioration of retinal ganglion …