Mechanisms of action of atypical antipsychotic drugs: implications for novel therapeutic strategies for schizophrenia
The mechanisms which contribute to the actions of atypical antipsychotic drugs, such as
clozapine and the putative atypical agents remoxipride and raclopride, are reviewed …
clozapine and the putative atypical agents remoxipride and raclopride, are reviewed …
Metabotropic glutamate receptors for new treatments in schizophrenia
Metabotropic glutamate receptors (mGluRs) represent exciting targets for the development
of novel therapeutic agents for schizophrenia. Recent studies indicate that selective …
of novel therapeutic agents for schizophrenia. Recent studies indicate that selective …
Dopamine autoreceptor agonists as potential antipsychotics. 3. 6-Propyl-4, 5, 5a, 6, 7, 8-hexahydrothiazolo [4, 5-f] quinolin-2-amine
BW Caprathe, JC Jaen, LD Wise… - Journal of medicinal …, 1991 - ACS Publications
A series of rigid tricyclic analogues of the dopamine (DA) agonist PD 118440 [4-(l, 2, 5, 6-
tetrahydro-l-propyl-3-pyridinyl)-2-thiazolamine] was synthesized and evaluated for …
tetrahydro-l-propyl-3-pyridinyl)-2-thiazolamine] was synthesized and evaluated for …
Dopamine autoreceptor agonists as potential antipsychotics. 2.(Aminoalkoxy)-4H-1-benzopyran-4-ones
JC Jaen, LD Wise, TG Heffner… - Journal of medicinal …, 1991 - ACS Publications
The synthesis and pharmacological properties of a novel type of [(arylpiperazinyl) alkoxy]-
4H-l-benzopyran-4-ones with dopaminergic activity are described. The nature of the …
4H-l-benzopyran-4-ones with dopaminergic activity are described. The nature of the …
Aryl 1-But-3-ynyl-4-phenyl-1, 2, 3, 6-tetrahydropyridines as Potential Antipsychotic Agents: Synthesis and Structure− Activity Relationships
SA Glase, HC Akunne, TG Heffner… - Journal of medicinal …, 1996 - ACS Publications
A novel series of aryl 1-but-3-ynyl-4-phenyl-1, 2, 3, 6-tetrahydropyridines with dopaminergic
activity is described. The structure− activity relationships of this series were studied by …
activity is described. The structure− activity relationships of this series were studied by …
Structure‐activity and conformational studies of a series of modified C‐terminal hexapeptide neurotensin analogues
DL HEYL, NM SEFLER, JX HE… - … journal of peptide …, 1994 - Wiley Online Library
Neurotensin (NT), is a linear tetradecapeptide (pGlu1‐Leu2‐Tyr3‐Glu4‐Asn5‐Lys6‐Pro7‐
Arg8‐Arg9‐Pro10‐Tyr11‐Ile12‐Leu13) that has been found in the central nervous system …
Arg8‐Arg9‐Pro10‐Tyr11‐Ile12‐Leu13) that has been found in the central nervous system …
The discovery and structure-activity relationships of 1, 2, 3, 6-tetrahydro-4-phenyl-1-[(arylcyclohexenyl) alkyl] pyridines. Dopamine autoreceptor agonists and potential …
JL Wright, BW Caprathe, DM Downing… - Journal of medicinal …, 1994 - ACS Publications
A novel dopamine (DA) autoreceptoragonist, l, 2, 3, 6-tetrahydro-4-phenyl-l-[(3-phenyl-3-
cyclohexen-l-yl) methyl] pyridine (14), was identified. The structure-activity relationships …
cyclohexen-l-yl) methyl] pyridine (14), was identified. The structure-activity relationships …
Differential effects of the nonpeptide neurotensin antagonist, SR 48692, on the pharmacological effects of neurotensin agonists
TA Pugsley, HC Akunne, SZ Whetzel, S Demattos… - Peptides, 1995 - Elsevier
In in vitro studies, SR 48692, a nonpeptide neurotensin receptor antagonist, inhibited the
binding of [3H] or [125I] neurotensin to membrane preparations from 10-day-old mouse …
binding of [3H] or [125I] neurotensin to membrane preparations from 10-day-old mouse …
Synthesis of the enantiomers of reduced haloperidol
JC Jaen, BW Caprathe, S Priebe, LD Wise - Pharmaceutical research, 1991 - Springer
Reduced haloperidol (RHAL) is the best known metabolite of haloperidol (HAL), having
been identified in humans, rats, and guinea pigs. Since RHAL contains an asymmetric …
been identified in humans, rats, and guinea pigs. Since RHAL contains an asymmetric …
Lack of involvement of haloperidol-sensitive sigma binding sites in modulation of dopamine neuronal activity and induction of dystonias by antipsychotic drugs
LT Meltzer, CL Christoffersen, KA Serpa, TA Pugsley… - …, 1992 - Elsevier
The present studies evaluated previous suggestions that haloperidol-sensitive sigma
binding sites are involved in the modulation of dopamine (DA) neuronal activity and in the …
binding sites are involved in the modulation of dopamine (DA) neuronal activity and in the …