Gut microbiota-dependent marker TMAO in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target

S Yang, X Li, F Yang, R Zhao, X Pan, J Liang… - Frontiers in …, 2019 - frontiersin.org
Cardiovascular disease (CVD) is the leading cause of death worldwide, especially in
developed countries, and atherosclerosis (AS) is the common pathological basis of many …

Endothelial dysfunction and hypertension

D Konukoglu, H Uzun - Hypertension: from basic research to clinical …, 2017 - Springer
In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is
known to be a tissue regulating vascular tone, cell growth and the interaction between the …

Gut microbiota-derived metabolites in CRC progression and causation

N Dalal, R Jalandra, N Bayal, AK Yadav… - Journal of Cancer …, 2021 - Springer
Background Based on recent research reports, dysbiosis and improper concentrations of
microbial metabolites in the gut may result into the carcinogenesis of colorectal cancer …

The aging risk and atherosclerosis: a fresh look at arterial homeostasis

T Head, S Daunert, PJ Goldschmidt-Clermont - Frontiers in genetics, 2017 - frontiersin.org
A considerable volume of research over the last decade has focused on understanding the
fundamental mechanisms for the progression of atherosclerosis—the underlying cause for …

Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning

J Wang, Z Kang, Y Liu, Z Li, Y Liu, J Liu - Frontiers in immunology, 2022 - frontiersin.org
Objective The decreased stability of atherosclerotic plaques increases the risk of ischemic
stroke. However, the specific characteristics of dysregulated immune cells and effective …

The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis

S Geng, K Chen, R Yuan, L Peng, U Maitra… - Nature …, 2016 - nature.com
Sustained low-grade inflammation mediated by non-resolving inflammatory monocytes has
long been suspected in the pathogenesis of atherosclerosis; however, the molecular …

Lipoic acid: its antioxidant and anti-inflammatory role and clinical applications

F Andrea Moura, K Queiroz de Andrade… - Current Topics in …, 2015 - ingentaconnect.com
Lipoic acid (LA) is an antioxidant able to produce its effects in aqueous or lipophilic
environments. Lipoate is the conjugate base of lipoic acid, and the most prevalent form of LA …

Mesenchymal stem cell-derived exosomal miR-21a-5p promotes M2 macrophage polarization and reduces macrophage infiltration to attenuate atherosclerosis

J Ma, L Chen, X Zhu, Q Li, L Hu… - Acta biochimica et …, 2021 - academic.oup.com
Atherosclerosis (AS) is the main pathological basis for ischemic cardiovascular and
cerebrovascular diseases. Mesenchymal stem cell (MSC)-derived exosomes have the …

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates

JA Mattison, M Wang, M Bernier, J Zhang, SS Park… - Cell metabolism, 2014 - cell.com
Central arterial wall stiffening, driven by a chronic inflammatory milieu, accompanies arterial
diseases, the leading cause of cardiovascular (CV) morbidity and mortality in Western …

[HTML][HTML] Atherosclerosis and cancer; a resemblance with far-reaching implications

JV Tapia-Vieyra, B Delgado-Coello… - Archives of medical …, 2017 - Elsevier
Atherosclerosis and cancer are chronic diseases considered two of the main causes of
death all over the world. Taking into account that both diseases are multifactorial, they share …