Targeting nanoparticles to malignant tissues for improved diagnosis and therapy is a
popular concept. However, after surveying the literature from the past 10 years, only …

For a long time, cysteine cathepsins were considered primarily as proteases crucial for
nonspecific bulk proteolysis in the endolysosomal system. However, this view has …

The ever-growing use of inorganic nanoparticles (NPs) in biomedicine provides an exciting
approach to develop novel imaging and drug delivery systems, owing to the ease with which …

Cysteine cathepsin protease activity is frequently dysregulated in the context of neoplastic
transformation. Increased activity and aberrant localization of proteases within the tumour …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Similarities between tumors and the inflammatory response associated with wound healing
have been recognized for more than 150 years and continue to intrigue. Some years ago …

The blood vessels supplying tumors are strikingly heterogeneous and differ from their
normal counterparts with respect to organization, structure, and function. Six distinctly …

Judah Folkman recognized that new blood vessel formation is important for tumor growth
and proposed antiangiogenesis as a novel approach to cancer therapy. Discovery of …

Extracellular matrix (ECM) is essential for all stages of angiogenesis. In the adult,
angiogenesis begins with endothelial cell (EC) activation, degradation of vascular basement …

Since the discovery of the key role of cathepsin K in bone resorption, cysteine cathepsins
have been investigated by pharmaceutical companies as drug targets. The first clinical …