The early developing retinal neuroepithelium is composed of multipotent retinal progenitor
cells that differentiate in a time specific manner, giving rise to six major types of neuronal …

Across all species, retinal ganglion cells (RGCs) are the first retinal neurons generated
during development, followed by the other retinal cell types. How are retinal progenitor cells …

Vertebrate retinal progenitor cells (RPCs) are pluripotent, but pass through competence
states that progressively restrict their developmental potential (;;). In the rodent eye, seven …

Considerable progress has been made in understanding the mechanisms that control the
production of specialized neuronal types. However, how the timing of differentiation …

During the development of the spinal cord, proliferative neural progenitors differentiate into
postmitotic neurons with distinct fates. How cells switch from progenitor states to …

During vertebrate development, the central (CNS) and peripheral nervous systems (PNS)
arise from the neural plate. Cells at the margin of the neural plate give rise to neural crest …

The generation of diverse neuronal types and subtypes from multipotent progenitors during
development is crucial for assembling functional neural circuits in the adult central nervous …

Abstract Purpose of Review Notch signaling is an important component of retinal progenitor
cell maintenance and Muller glia (MG) specification during development, and its …

In the vertebrate eye, Notch ligands, receptors, and ternary complex components determine
the destiny of retinal progenitor cells in part by regulating Hes effector gene activity. There …

Primary liver cancer, which includes hepatocellular carcinoma (HCC), intrahepatic
cholangiocarcinoma (ICC) and fibrolamellar HCC, is one of the most common malignancies …