Round cell sarcomas represent a diagnostic challenge for pathologists, owing to the poorly
differentiated features of these high‐grade tumours. The diagnosis of round cell sarcoma …

With an annual incidence of less than 1%, Ewing sarcoma mainly occurs in children and
young adults. It is not a frequent tumor but is the second most common bone malignancy in …

Genetic studies in mice and human cancers established BCL11B as a haploinsufficient
tumor suppressor gene. Paradoxically, BCL11B is overexpressed in some human cancers …

Sarcoma, the second common type of solid tumor in children and adolescents, has a wide
variety of subtypes that are often not properly diagnosed at an early stage, leading to late …

Chromosomal instability (CIN) is a hallmark of cancer. Yet, many childhood cancers, such as
Ewing sarcoma (EwS), feature remarkably 'silent'genomes with minimal CIN. Here, we show …

Background: Ewing sarcoma (ES), the second most prevalent bone malignant tumor has no
widely known prognostic biomarker. Earlier studies have suggested that chaperonin …

Extracellular vesicles (EVs) are important mediators of intercellular communication in the
tumour microenvironment. Many studies suggest that cancer cells release higher amounts of …

Undifferentiated small round cell sarcomas of bone and soft tissue (USRS) are a group of
tumors with heterogenic genomic alterations sharing similar morphology. In the present …

The Krüppel-like transcription factor (KLF) BCL11B is characterized by a wide tissue
distribution and crucial functions in key developmental and cellular processes, as well as in …

Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly
affects children and adolescents. The pathognomonic oncofusion EWSR1:: FLI1 …