Organic molecules as well as metal complexes may exist as several geometric isomers1
which display distinct physical properties and chemical reactivities. A molecule containing …

Proline is unique in the realm of amino acids in its ability to adopt completely distinct cis and
trans conformations, which allows it to act as a backbone switch that is controlled by prolyl …

Orotic acid is decarboxylated with a half-time (t1/2) of 78 million years in neutral aqueous
solution at room temperature, as indicated by reactions in quartz tubes at elevated …

A long-standing challenge is to understand at the atomic level how protein dynamics
contribute to enzyme catalysis. X-ray crystallography can provide snapshots of …

Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase (PPIase) that is distinct
from members of two other families of conventional PPIases, cyclophilins and FKBPs (FK …

The human rotamase or peptidyl-prolyl cis-trans isomerase Pin1 is a conserved mitotic
regulator essential for the G2/M transition of the eukaryotic cell cycle. We report the 1.35 Å …

Cyclosporine A therapy for prophylaxis against graft rejection revolutionized human organ
transplantation. The immunosuppressant drugs cyclosporin A (CsA), FK506 and rapamycin …

The two-volume Encyclopedia of Supramolecular Chemistry offers authoritative, centralized
information on a rapidly expanding interdisciplinary field. User-friendly and high-quality …

Peptidyl-prolyl isomerases catalyze the conversion between cis and trans isomers of proline.
The cyclophilin family of peptidyl-prolyl isomerases is well known for being the target of the …

A cyclophilin‐D affinity matrix was employed to isolate components of the mitochondrial
permeability transition pore. A cDNA encoding cyclophilin‐D was cloned from a rat liver …