In recent years, the application of advanced analytics, especially artificial intelligence (AI), to
digital H&E images, and other histological image types, has begun to radically change how …

Fractal characteristics of chromatin, revealed by light or electron microscopy, have been
reported during the last 20 years. Fractal features can easily be estimated in digitalized …

Important concepts like fractal calculus and fractal analysis, the sum of squared residuals,
and Aikaike's information criterion must be thoroughly understood in order to correctly fit …

Lacunarity, a quantitative morphological measure of how shapes fill space, and fractal
dimension, a morphological measure of the complexity of pixel arrangement, have shown …

Most of what we know about gene transcription comes from the view of cells as molecular
machines: focusing on the role of molecular modifications to the proteins carrying out …

The multifractal analysis of binary images of DNA is studied in order to define a
methodological approach to the classification of DNA sequences. This method is based on …

Introduction: Fractality is omnipresent in medicine and life sciences. In particular, the fractal
principle is found simultaneously at different organization levels of the cell nucleus. The aim …

Background Nuclear alterations are a well-known manifestation of cancer. However, little is
known about the early, microscopically-undetectable stages of malignant transformation …

The organization of chromatin is a regulator of molecular processes including transcription,
replication, and DNA repair. The structures within chromatin that regulate these processes …

Three-dimensional supranucleosomal chromatin packing plays a profound role in
modulating gene expression by regulating transcription reactions through mechanisms such …