The ménage à trois of autophagy, lipid droplets and liver disease

Y Filali-Mouncef, C Hunter, F Roccio, S Zagkou… - Autophagy, 2022 - Taylor & Francis
Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

Autophagy: a multifaceted player in the fate of sperm

M Wang, L Zeng, P Su, L Ma, M Zhang… - Human Reproduction …, 2022 - academic.oup.com
BACKGROUND Autophagy is an intracellular catabolic process of degrading and recycling
proteins and organelles to modulate various physiological and pathological events …

The constructive and destructive impact of autophagy on both genders' reproducibility, a comprehensive review

M Samare-Najaf, A Neisy, A Samareh, D Moghadam… - Autophagy, 2023 - Taylor & Francis
Reproduction is characterized by a series of massive renovations at molecular, cellular, and
tissue levels. Recent studies have strongly tended to reveal the involvement of basic …

Hypoxia and selective autophagy in cancer development and therapy

I Daskalaki, I Gkikas, N Tavernarakis - Frontiers in cell and …, 2018 - frontiersin.org
Low oxygen availability, a condition known as hypoxia, is a common feature of various
pathologies including stroke, ischemic heart disease, and cancer. Hypoxia adaptation …

The expanding role of mitochondria, autophagy and lipophagy in steroidogenesis

G Bassi, SK Sidhu, S Mishra - Cells, 2021 - mdpi.com
The fundamental framework of steroidogenesis is similar across steroidogenic cells,
especially in initial mitochondrial steps. For instance, the START domain containing protein …

The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells

C Miceli, F Roccio, L Penalva-Mousset, M Burtin… - Nature cell …, 2020 - nature.com
Organs and cells must adapt to shear stress induced by biological fluids, but how fluid flow
contributes to the execution of specific cell programs is poorly understood. Here we show …

Role of hypoxia-mediated autophagy in tumor cell death and survival

RF Zaarour, B Azakir, EY Hajam, H Nawafleh… - Cancers, 2021 - mdpi.com
Simple Summary Autophagy is a self-eating mechanism that is involved in the degradation
of organelles and cellular materials. It is initiated by intracellular and extracellular stress …

Impact of hypoxia on male reproductive functions

PA Oyedokun, RE Akhigbe, LO Ajayi… - Molecular and Cellular …, 2023 - Springer
Male reproductive functions, which include testicular steroidogenesis, spermatogenesis, and
sexual/erectile functions are key in male fertility, but may be adversely altered by several …

Autophagy: A double-edged sword in male reproduction

Q Yan, Y Zhang, Q Wang, L Yuan - International Journal of Molecular …, 2022 - mdpi.com
Autophagy, an evolutionarily conserved cell reprogramming mechanism, exists in all
eukaryotic organisms. It is a fundamental and vital degradation/recycling pathway that …

Autophagy in male reproduction

Y Zhu, Q Yin, D Wei, Z Yang, Y Du… - Systems biology in …, 2019 - Taylor & Francis
Autophagy is a fundamental process that exists in all eukaryotic organisms, with a primary
function of catabolizing undesirable components to provide energy and essential materials …