Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant
and escalating global challenges. Its etiology is intricate and diverse, stemming from a …

Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Microglia are so versatile that they not only provide immune surveillance for central nervous
system, but participate in neural circuitry development, brain blood vessels formation, blood …

Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

Human genetics and preclinical studies have identified key contributions of TREM2 to
several neurodegenerative conditions, inspiring efforts to modulate TREM2 therapeutically …

Microglia, as immune cells in the central nervous system, are closely related to cognitive
impairment associated with type 2 diabetes (T2D). Preliminary explorations have …

The complement system is increasingly recognized as a key player in the synapse loss and
cognitive impairments observed in Alzheimer's disease (AD). In particular, the process of …

Microglia are tissue-resident macrophages and professional phagocytes of the central
nervous system (CNS). In development, microglia-mediated phagocytosis is important for …

Alzheimer's disease is a chronic degenerative disease of the central nervous system, which
primarily affects elderly people and accounts for 70-80% of dementia cases. The current …

Microglia play a crucial role in interacting with neuronal synapses and modulating synaptic
plasticity. This function is particularly significant during postnatal development, as microglia …