Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

Collateral sensitivity (CS) is an evolutionary trade-off traditionally linked to the mutational
acquisition of antibiotic resistance (AR). However, AR can be temporally induced, and the …

The acquisition of resistance to one antibiotic sometimes leads to collateral sensitivity to a
second antibiotic. Here, we show that vancomycin resistance in Enterococcus faecium is …

Collateral sensitivity is an evolutionary trade-off whereby acquisition of the adaptive
phenotype of resistance to an antibiotic leads to the nonadaptive increased susceptibility to …

Functional metagenomics is a powerful experimental tool to identify antibiotic resistance
genes (ARGs) in the environment, but the range of suitable host bacterial species is limited …

Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …

Evolution is at the core of the impending antibiotic crisis. Sustainable therapy must thus
account for the adaptive potential of pathogens. One option is to exploit evolutionary trade …

Background Some antibiotic pairs display a property known as collateral sensitivity in which
the evolution of resistance to one antibiotic increases sensitivity to the other. Alternating …

Populations often encounter changed environments that remove selection for the
maintenance of particular phenotypic traits. The resulting genetic decay of those traits under …