Ultraviolet (UV) irradiation causes various types of DNA damage, which leads to specific
mutations and the emergence of skin cancer in humans, often decades after initial exposure …

This review chapter presents a critical survey of the main available information on the UVB
and UVA bipyrimidine photoproducts which constitute the predominant recipient classes of …

Sunlight-associated melanomas carry a unique C-to-T mutation signature. UVB radiation
induces cyclobutane pyrimidine dimers (CPDs) as the major form of DNA damage, but the …

Cyclobutane pyrimidine dimers (CPDs) are the major products of DNA produced by direct
absorption of UV light, and result in C to T mutations linked to human skin cancers. Most …

DNA methylation, occurring at the 5 position of cytosine, is a natural process associated with
mutational hotspots in skin tumors. By combining experimental techniques (optical …

Background: Guanine-rich DNA can fold into highly stable four-stranded DNA structures
called G-quadruplexes (G4). In recent years, the G-quadruplex field has blossomed as new …

Epigenetic DNA modifications are essential for normal cell function in vertebrates, but they
can also be hotspots of mutagenesis. Methylcytosine in particular has long been known to …

Ultraviolet radiation (UVR) predominantly induces UV-signature mutations, C→ T and CC→
TT base substitutions at dipyrimidine sites, in the cellular and skin genome. I observed in our …

C5-methylation of cytosines is strongly correlated with UV-induced mutations detected in
skin cancers. Mutational hot-spots appearing at TCG sites are due to the formation of …

Sunlight-induced C to T mutation hot spots in skin cancers occur primarily at methylated
CpG sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) …