Methods. A literature search using the databases Medscape, Pubmed, UpToDate and
EBSCO from 1945 to 2015. Results and Conclusions. Genetic predisposition/hereditary …

Polymorphisms in genes encoding proteins involved in vitamin D metabolism and transport
are recognised to influence vitamin D status. Syntheses of genetic association studies …

Increasing scientific evidence supports the link between vitamin D and cancer risk. The
active metabolite 1, 25 (OH) 2D exerts its activity by binding to the vitamin D receptor (VDR) …

Background: Kidney disease is a serious problem that adversely affects human health, but
critical knowledge is lacking on how to effectively treat established chronic kidney disease …

Abstract Antiproliferative effects of 1, 25-dihydroxyvitamin D, the biologically active form of
vitamin D, are well established in various cell types by influencing cell differentiation and …

Cancer is a major health problem and cause of death worldwide that accounted for 7.6
million deaths in 2008, which is projected to continue rising with an estimated 13.1 million …

Numerous studies investigated the associations of VDR polymorphisms with various types of
cancer, suggesting an influence on cancer risk. FokI is one of the most frequently analysed …

Multiple myeloma (MM) is a plasma cell malignancy frequently accompanied with skeletal co-
morbidity. Vitamin D (1, 25 (OH) 2 D) is an important mediator of skeletal homeostasis that …

Molecular epidemiologic studies previously reported that 1, 25-dihydroxy vitamin D3 (1, 25
(OH) 2 D3) appears to influence cancer risk. It exerts its activity through the intracellular …

The VDR gene is an important regulator of the vitamin D pathway, and the role of some of its
polymorphisms on cancer risk was previously investigated. A trend of cancer risk reduction …