The observation that unhealthy diets (those that are low in whole grains, fruits and
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …

Chronic kidney disease (CKD) is a major global health problem with an increasing
prevalence partly driven by aging population structure. Both genomic and environmental …

During chronic kidney disease (CKD), typical alterations in the gut microbiota are observed.
The kidney no longer plays the role of the main excretory organ as this function is performed …

Renal disease is the common denominator of a number of underlying disease conditions,
whose prevalence has been dramatically increasing over the last two decades. Two aspects …

The SS (Dahl salt sensitive) rat is an established model of hypertension and renal damage
that is accompanied with immune system activation in response to a high-salt diet …

A subset of individuals with type 1 diabetes will develop diabetic kidney disease (DKD).
DKD is heritable and large-scale genome-wide association studies have begun to identify …

Chronic kidney disease (CKD) is defined as a decrease in renal function or glomerular
filtration rate (GFR), and proteinuria is often present. Proteinuria increases with age and can …

Metabolite, also known as intermediate metabolite, refers to substances produced or
consumed in the metabolic processes. There are growing evidences that metabolites play …

Background Diabetic nephropathy (DN) has an increasing global prevalence with excessive
health expenditure and burden. Exosomal mRNAs regulate intercellular communications …

Background: Although knowledge of the genetic factors influencing kidney disease is
increasing, epigenetic profiles, which are associated with chronic kidney disease (CKD) …