Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …

Mitochondrial DNA (mtDNA) faces the universal challenges of genome maintenance: the
accurate replication, transmission and preservation of its integrity throughout the life of the …

R loops arising during transcription induce genomic instability, but how cells respond to the
R loop-associated genomic stress is still poorly understood. Here, we show that cells …

Many years of extensive studies of metazoan mitochondrial genomes have established
differences in gene arrangements and genetic codes as valuable phylogenetic markers …

Elucidation of the process of DNA replication in mitochondria is in its infancy. For many
years, maintenance of the mitochondrial genome was regarded as greatly simplified …

Using two‐dimensional agarose gel electrophoresis, we show that mitochondrial DNA
(mtDNA) replication of birds and mammals frequently entails r ibonucleotide i ncorporation t …

While the majority of DNA is enclosed within the nucleus, the mitochondria also contain their
own, separate DNA, the mitochondrial DNA (mtDNA). Mutations in mtDNA are associated …

The established strand-displacement model for mammalian mitochondrial DNA (mtDNA)
replication has recently been questioned in light of new data using two-dimensional (2D) …

The mitochondrial genome (mtDNA) represents a tiny fraction of the whole genome,
comprising just 16.6 kilobases encoding 37 genes involved in oxidative phosphorylation …

Mutations in mitochondrial DNA (mtDNA) cause maternally inherited diseases, while
somatic mutations are linked to common diseases of aging. Although mtDNA mutations …