Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

STUDY QUESTION Can complete oocyte development be achieved from human ovarian
tissue containing primordial/unilaminar follicles and grown in vitro in a multi-step culture to …

Premature ovarian failure and infertility are major side effects of chemotherapy treatments in
young cancer patients. A more thorough understanding of the mechanism behind …

STUDY QUESTION How does biochemical stimulation or inhibition of the PI3K/Akt/mTOR
pathway affect the activation and the growth of human primordial follicles in vitro …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Theca cells function in a diverse range of necessary roles during folliculogenesis; to
synthesize androgens, provide crosstalk with granulosa cells and oocytes during …

Cryopreservation of ovarian tissue to preserve the fertility of girls and young women at high
risk of sterility is now widely practiced. Pieces of cryopreserved ovarian cortex can be …

In vitro follicle growth is a potential approach to preserve fertility for young women who are
facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our …

The increasing number of young survivors of cancer who have favorable outcomes
necessitates planning for the preservation of fertility, which may mean modifying the strategy …