Targeting mitosis in cancer: emerging strategies

C Dominguez-Brauer, KL Thu, JM Mason, H Blaser… - Molecular cell, 2015 - cell.com
The cell cycle is an evolutionarily conserved process necessary for mammalian cell growth
and development. Because cell-cycle aberrations are a hallmark of cancer, this process has …

Cell cycle regulation by the NEK family of protein kinases

AM Fry, L O'Regan, SR Sabir… - Journal of cell …, 2012 - journals.biologists.com
Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus
nidulans led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is …

Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms

N Jura, X Zhang, NF Endres, MA Seeliger, T Schindler… - Molecular cell, 2011 - cell.com
In contrast to the active conformations of protein kinases, which are essentially the same for
all kinases, inactive kinase conformations are structurally diverse. Some inactive …

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

O Fedorov, B Marsden, V Pogacic… - Proceedings of the …, 2007 - National Acad Sciences
Protein kinases play a pivotal role in cell signaling, and dysregulation of many kinases has
been linked to disease development. A large number of kinase inhibitors are therefore …

Genetics and expression profile of the tubulin gene superfamily in breast cancer subtypes and its relation to taxane resistance

B Nami, Z Wang - Cancers, 2018 - mdpi.com
Taxanes are a class of chemotherapeutic agents that inhibit cell division by disrupting the
mitotic spindle through the stabilization of microtubules. Most breast cancer (BC) tumors …

Targeting NEK2 as a promising therapeutic approach for cancer treatment

Y Fang, X Zhang - Cell Cycle, 2016 - Taylor & Francis
ABSTRACT Never in Mitosis (NIMA) Related Kinase 2 (NEK2) plays a key role in regulating
mitotic processes, including centrosome duplication and separation, microtubule …

Mitotic regulation by NIMA-related kinases

L O'regan, J Blot, AM Fry - Cell division, 2007 - Springer
The NIMA-related kinases represent a family of serine/threonine kinases implicated in cell
cycle control. The founding member of this family, the NIMA kinase of Aspergillus nidulans …

Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling

J Alexander, D Lim, BA Joughin, B Hegemann… - Science …, 2011 - science.org
The timing and localization of events during mitosis are controlled by the regulated
phosphorylation of proteins by the mitotic kinases, which include Aurora A, Aurora B, Nek2 …

Phosphatases in mitosis: roles and regulation

M Moura, C Conde - Biomolecules, 2019 - mdpi.com
Mitosis requires extensive rearrangement of cellular architecture and of subcellular
structures so that replicated chromosomes can bind correctly to spindle microtubules and …

Mitotic regulation by NEK kinase networks

AM Fry, R Bayliss, J Roig - Frontiers in cell and developmental biology, 2017 - frontiersin.org
Genetic studies in yeast and Drosophila led to identification of cyclin-dependent kinases
(CDKs), Polo-like kinases (PLKs) and Aurora kinases as essential regulators of mitosis …