Shear-dependent platelet aggregation: mechanisms and therapeutic opportunities
A Rana, E Westein, B Niego… - Frontiers in cardiovascular …, 2019 - frontiersin.org
Cardiovascular diseases (CVD) are the number one cause of morbidity and death
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …
Integrin conformational dynamics and mechanotransduction
The function of the integrin family of receptors as central mediators of cell-extracellular
matrix (ECM) and cell–cell adhesion requires a remarkable convergence of interactions and …
matrix (ECM) and cell–cell adhesion requires a remarkable convergence of interactions and …
Live-cell super-resolved PAINT imaging of piconewton cellular traction forces
Despite the vital role of mechanical forces in biology, it still remains a challenge to image
cellular force with sub-100-nm resolution. Here, we present tension points accumulation for …
cellular force with sub-100-nm resolution. Here, we present tension points accumulation for …
PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition
Despite the clinical success of blocking its interactions, how PD-1 inhibits T-cell activation is
incompletely understood, as exemplified by its potency far exceeding what might be …
incompletely understood, as exemplified by its potency far exceeding what might be …
Metal–organic‐framework‐derived carbon nanostructures for site‐specific dual‐modality photothermal/photodynamic thrombus therapy
Abstract Although near‐infrared (NIR)‐light‐mediated photothermal thrombolysis has been
investigated to overcome the bleeding risk of clinical clot‐busting agents, the secondary …
investigated to overcome the bleeding risk of clinical clot‐busting agents, the secondary …
Detection of cellular traction forces via the force-triggered Cas12a-mediated catalytic cleavage of a fluorogenic reporter strand
Molecular forces generated by cell receptors are infrequent and transient, and hence difficult
to detect. Here we report an assay that leverages the CRISPR-associated protein 12a …
to detect. Here we report an assay that leverages the CRISPR-associated protein 12a …
A reversible shearing DNA probe for visualizing mechanically strong receptors in living cells
H Li, C Zhang, Y Hu, P Liu, F Sun, W Chen… - Nature Cell …, 2021 - nature.com
In the last decade, DNA-based tension sensors have made significant contributions to the
study of the importance of mechanical forces in many biological systems. Albeit successful …
study of the importance of mechanical forces in many biological systems. Albeit successful …
Computational modeling for intelligent surface plasmon resonance sensor design and experimental schemes for real‐time plasmonic biosensing: A Review
The spectacular physical phenomenon of surface plasmon resonance (SPR) is the essence
of present‐day plasmonic sensors. Meanwhile, the unique properties of the interaction …
of present‐day plasmonic sensors. Meanwhile, the unique properties of the interaction …
Wettability-patterned microchip for emerging biomedical materials and technologies
Y Li, BF Liu, X Zhang - Materials Today, 2021 - Elsevier
Microchip has long been studied and facilitated recent investigations in multiple biomedical
and material fields. The advances in functional materials triggered several leaps in the …
and material fields. The advances in functional materials triggered several leaps in the …
Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms
As blood transitions from steady laminar flow (S-flow) in healthy arteries to disturbed flow (D-
flow) in aneurysmal arteries, platelets are subjected to external forces. Biomechanical …
flow) in aneurysmal arteries, platelets are subjected to external forces. Biomechanical …