Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

Systemic sclerosis (SSc) is a systemic autoimmune disease affecting multiple organ
systems, including the lungs. Interstitial lung disease (ILD) is the leading cause of death in …

Objective Interstitial lung disease (ILD) in systemic sclerosis (SS c) runs a highly variable
course, and prediction tools are highly desired. The aim of this study was to assess the …

Biomarkers have the potential to become central to the clinical evaluation and monitoring of
patients with chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype …

Autoimmune rheumatic diseases are characterised by an abnormal immune system
response, complement activation, cytokines dysregulation and inflammation. In last years …

Systemic sclerosis is an autoimmune disease leading to vasculopathy and fibrosis of skin
and internal organs. Despite likely shared pathogenic mechanisms, the patterns of skin and …

SSc is a rare disease of unknown origin associated with multiple organ involvement. One of
the major complications that drives the mortality of SSc patients is interstitial lung disease …

G protein-coupled receptors (GPCRs) comprise the largest and most diverse family of
integral membrane proteins that participate in different physiological processes such as the …

Contemporary studies of systemic sclerosis consistently demonstrate that interstitial lung
disease is a leading cause of disease-related death. This review summarizes morbidity and …

Systemic sclerosis (SSc) is a chronic, multisystem connective tissue, and autoimmune
disease with the highest case-specific mortality and complications among rheumatic …