The S100 family of proteins contains 25 known members that share a high degree of
sequence and structural similarity. However, only a limited number of family members have …

Rheumatic diseases are characterized by sterile inflammation that causes severe long-term
damage to various organ systems. A growing body of evidence supports a pivotal role for the …

High recurrence and metastasis of triple-negative breast cancer (TNBC) after operation is a
leading cause of breast cancer related death. The pre-metastatic niche (PMN) is an …

Background The peroxisome proliferator-activated receptor γ (PPAR-γ)-dependent
upregulation of fatty acid oxidation (FAO) mediates protumor (also known as M2-like) …

The metastasis-promoting S100A4 protein, a member of the S100 family, has recently been
discovered as a potent factor implicated in various inflammation-associated diseases …

Background: Despite the better prognosis given by surgical resection and chemotherapy in
low-grade glioma (LGG), progressive transformation is still a huge concern. In this case, the …

The process of uncontrolled internal scarring, called fibrosis, is now emerging as a
pathological feature shared by both peripheral and central nervous system diseases. In the …

Fibrosis is characterized by fibroblast activation, extracellular matrix (ECM) accumulation
and infiltration of inflammatory cells that sometimes leads to irreversible organ dysfunction …

Idiopathic pulmonary fibrosis (IPF) represents a chronic progressive fibrotic interstitial lung
disease of unknown cause with an ominous prognosis. It remains an unprecedent clinical …

Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR) α and β/δ agonist
that has reached a phase III clinical trial for the treatment of metabolic dysfunction …