Association of betel nut with carcinogenesis: revisit with a clinical perspective

RN Sharan, R Mehrotra, Y Choudhury, K Asotra - 2012 - journals.plos.org
Betel nut (BN), betel quid (BQ) and products derived from them are widely used as a socially
endorsed masticatory product. The addictive nature of BN/BQ has resulted in its widespread …

Glutathione S-transferase theta 1 (GSTT1) deletion polymorphism and susceptibility to head and neck carcinoma: a systematic review with five analyses

S Sadafi, P Choubsaz, SMM Kazemeini, MM Imani… - BMC cancer, 2024 - Springer
Glutathione S-transferase theta 1 (GSTT1) enzyme plays a key role in the neutralization of
electrophilic compounds such as carcinogens. Herein, we aimed to evaluate GSTT1 …

Health effects associated with chewing tobacco: a Burden of Proof study

GF Gil, JA Anderson, A Aravkin, K Bhangdia… - Nature …, 2024 - nature.com
Chewing tobacco use poses serious health risks; yet it has not received as much attention
as other tobacco-related products. This study synthesizes existing evidence regarding the …

Multiple analytical approaches reveal distinct gene-environment interactions in smokers and non smokers in lung cancer

R Ihsan, PS Chauhan, AK Mishra, DS Yadav… - PloS one, 2011 - journals.plos.org
Complex disease such as cancer results from interactions of multiple genetic and
environmental factors. Studying these factors singularly cannot explain the underlying …

GSTT1 null genotype is a risk factor for diabetic retinopathy in Caucasians with type 2 diabetes, whereas GSTM1 null genotype might confer protection against …

I Cilenšek, S Mankoč, MG Petrovič… - Disease …, 2012 - Wiley Online Library
Aim: Substantial data indicate that oxidative stress is involved in the development of diabetic
retinopathy (DR). The aim of the present study was to investigate whether the genetic …

Signature of genetic associations in oral cancer

V Sharma, A Nandan, AK Sharma, H Singh… - Tumor …, 2017 - journals.sagepub.com
Oral cancer etiology is complex and controlled by multi-factorial events including genetic
events. Candidate gene studies, genome-wide association studies, and next-generation …

The Flemish Environment and Health Study (FLEHS)–second survey (2007–2011): establishing reference values for biomarkers of exposure in the Flemish population

G Schoeters, A Colles, ED Hond, K Croes, J Vrijens… - 2011 - books.rsc.org
Care as a legal recognition of environmental health. The Decree1 made it mandatory for the
Flemish government to perform an HBM program, which is an important policy signal of …

Association between GSTM1, GSTT1, and GSTP1 polymorphisms and lung cancer risk in a Turkish population

AO Ada, SC Kunak, F Hancer, E Soydas, S Alpar… - Molecular biology …, 2012 - Springer
Several studies focused on investigating genetic polymorphisms in order to estimate genetic
contribution to lung cancer often showed conflicting results. In this study, we investigated the …

[PDF][PDF] Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors

ZH Chen, JF Xian, LP Luo - Genet Mol Res, 2017 - funpecrp.com.br
Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes;
GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms …

Null genotypes of Glutathione S-transferase M1 and T1 and risk of oral cancer: A meta-analysis

KV Kumar, A Goturi, M Nagaraj… - Journal of Oral and …, 2022 - journals.lww.com
Background: Glutathione S-transferase M1 (GSTM1) and Glutathione S-transferase T1
(GSTT1) null genotypes have been considered risk factors for many cancers. Numerous …