Understanding Clostridium difficile colonization

MJT Crobach, JJ Vernon, VG Loo… - Clinical microbiology …, 2018 - Am Soc Microbiol
Clostridium difficile is the main causative agent of antibiotic-associated and health care-
associated infective diarrhea. Recently, there has been growing interest in alternative …

Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection

P Spigaglia - Therapeutic advances in infectious disease, 2016 - journals.sagepub.com
Clostridium difficile epidemiology has changed in recent years, with the emergence of highly
virulent types associated with severe infections, high rates of recurrences and mortality …

Clostridium difficile infection following systemic antibiotic administration in randomised controlled trials: a systematic review and meta-analysis

KZ Vardakas, KK Trigkidis, E Boukouvala… - International journal of …, 2016 - Elsevier
Antibiotics have been the most important risk factor for Clostridium difficile infection (CDI).
However, only data from non-randomised studies have been reviewed. We sought to …

Dissemination of Clostridium difficile in food and the environment: Significant sources of C. difficile community‐acquired infection?

K Warriner, C Xu, M Habash, S Sultan… - Journal of applied …, 2017 - academic.oup.com
Clostridium difficile is a significant pathogen with over 300 000 cases reported in North
America annually. Previously, it was thought that C. difficile was primarily a clinically …

Genomic Delineation of Zoonotic Origins of Clostridium difficile

DR Knight, TV Riley - Frontiers in public health, 2019 - frontiersin.org
Clostridium difficile is toxin-producing antimicrobial resistant (AMR) enteropathogen
historically associated with diarrhea and pseudomembranous colitis in hospitalized patients …

Non-human C. difficile Reservoirs and Sources: Animals, Food, Environment

C Rodriguez Diaz, C Seyboldt, M Rupnik - Updates on Clostridium difficile …, 2018 - Springer
Clostridium difficile is ubiquitous and is found in humans, animals and in variety of
environments. The substantial overlap of ribotypes between all three main reservoirs …

Increasing antibiotic resistance in Clostridioides difficile: A systematic review and meta-analysis

S Saha, S Kapoor, R Tariq, AN Schuetz, PK Tosh… - Anaerobe, 2019 - Elsevier
Background Decreases in clinical response of Clostridioides difficile to antibiotics used for
its treatment have raised concerns regarding antibiotic resistance. We conducted a …

Antimicrobial Resistance and Reduced Susceptibility in Clostridium difficile: Potential Consequences for Induction, Treatment, and Recurrence of C. difficile Infection

SD Baines, MH Wilcox - Antibiotics, 2015 - mdpi.com
Clostridium difficile infection (CDI) remains a substantial burden on healthcare systems and
is likely to remain so given our reliance on antimicrobial therapies to treat bacterial …

A Role for Tetracycline Selection in Recent Evolution of Agriculture-Associated Clostridium difficile PCR Ribotype 078

KE Dingle, X Didelot, TP Quan, DW Eyre, N Stoesser… - MBio, 2019 - Am Soc Microbiol
The increasing clinical importance of human infections (frequently severe) caused by
Clostridium difficile PCR ribotype 078 (RT078) was first reported in 2008. The severity of …

Presence of Clostridium difficile in pig faecal samples and wild animal species associated with pig farms

S Andrés‐Lasheras, R Bolea… - Journal of Applied …, 2017 - academic.oup.com
Aims To determine the presence of Clostridium difficile on fattening pig farms in north‐
eastern Spain. Methods and Results Twenty‐seven farms were sampled. Pools of pig faecal …