Astrocytes are a type of glial cell that tile the CNS. They interact with multiple cell types,
including neurons, glial cells and blood vessels, and are involved or implicated in brain …

Astrocytes are essential in maintaining normal brain functions such as blood brain barrier
(BBB) homeostasis and synapse formation as the most abundant cell type in the central …

Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation
of the CNS, including neuronal morphology and synapse refinement. Herein, we …

Microglia represent the primary resident immune cells of the central nervous system (CNS)
and modulate local immune responses. Depending on their physiological functions …

Stressors ranging from psychogenic/social to neurogenic/injury to systemic/microbial can
impact microglial inflammatory processes, but less is known regarding their effects on …

Single-cell analysis has become an established method to study cell heterogeneity and for
rare cell characterization. Despite the high cost and technical constraints, applications are …

Cancer metastasis to the brain is a significant clinical problem. Metastasis is the
consequence of favorable interactions between invaded cancer cells and the …

Background Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a
cascade of pathological changes in Alzheimer's disease (AD), and inhibiting BACE1, which …

Neurons require physiological IFN-γ signaling to maintain central nervous system (CNS)
homeostasis, however, pathological IFN-γ signaling can cause CNS pathologies. The …

A disabling consequence of stroke is cognitive impairment, occurring in 12%–48% of
patients, for which there is no therapy. A critical barrier is the lack of understanding of how …