The prefrontal cortex (PFC) is a brain region that is critically involved in cognitive function
and inhibitory control of behavior, and adolescence represents an important period of …

Alcohol use disorder (AUD) is a significant public health concern, contributing to a myriad of
social, psychological, and physiological issues. Despite substantial efforts within the alcohol …

Stress-related substance use is a major challenge for treating substance use disorders. This
selective review focuses on emerging pharmacotherapies with potential for reducing stress …

Rationale Women represent a vulnerable and growing population with respect to alcohol
abuse. Elevated glucocorticoid exposure in adolescence increases addiction risk and stress …

Chronic ethanol exposure leads to dysregulation of the hypothalamic-pituitary-adrenal axis,
leading to changes in glucocorticoid release and function that have been proposed to …

Background Factors leading to the harmful consumption of substances, like alcohol and
sucrose, involve a complex interaction of genes and the environment. While we cannot …

Background: The intermittent access 2-bottle choice (IA2BC) and drinking in the dark (DID)
models were developed for studying rodent binge-like consumption. Traditionally, IA2BC …

The lateral habenula (LHb) plays an important role in learning driven by negative outcomes.
Many drugs of abuse, including ethanol, have dose-dependent aversive effects that act to …

Despite promising preliminary biology, natural products isolation efforts may be confounded
when the active compound is not isolated during bioassay-guided purification or classical …

Rationale The correlation between stress and smoking is well established. The mechanisms
that underlie this relationship are, however, unclear. Recent data suggest that the kappa …