The Rich Chemistry Resulting from the 1, 3‐Dipolar Cycloaddition Reactions of Enamines and Azides

VA Bakulev, T Beryozkina, J Thomas… - European Journal of …, 2018 - Wiley Online Library
Enamines exhibit exceptionally high reactivity in their 1, 3‐dipolar cycloaddition reactions
with azides in comparison with other dipolarophiles. This review includes the reactions of …

Triazolization of Enolizable Ketones with Primary Amines: A General Strategy toward Multifunctional 1, 2, 3‐Triazoles

R Prakash, T Opsomer, W Dehaen - The Chemical Record, 2021 - Wiley Online Library
The development of metal‐free syntheses toward 1, 2, 3‐triazoles has been a burgeoning
research area throughout the past decade. Despite the numerous advances, the scarceness …

Metal-free syntheses of N-functionalized and NH-1, 2, 3-triazoles: an update on recent developments

T Opsomer, W Dehaen - Chemical Communications, 2021 - pubs.rsc.org
An overview of the latest developments in the metal-free synthesis of non-benzo-fused N-
functionalized and NH-1, 2, 3-triazoles is provided in this feature article. Synthetic studies …

Betulonic acid derivatives interfering with human coronavirus 229E replication via the nsp15 endoribonuclease

A Stevaert, B Krasniqi, B Van Loy… - Journal of medicinal …, 2021 - ACS Publications
To develop antiviral therapeutics against human coronavirus (HCoV) infections, suitable
coronavirus drug targets and corresponding lead molecules must be urgently identified …

1, 2, 3-Triazole-Mediated Synthesis of 1-Methyleneisoquinolines: A Three-Step Synthesis of Papaverine and Analogues

T Opsomer, M Van Hoof, A D'Angelo, W Dehaen - Organic letters, 2020 - ACS Publications
A metal-free three-step synthesis toward functionalized 1-methyleneisoquinolines from
readily available substrates is reported. First, acetal-containing 1, 2, 3-triazoles were …

General method of synthesis of 5-(het) arylamino-1, 2, 3-triazoles via Buchwald–Hartwig reaction of 5-amino-or 5-halo-1, 2, 3-triazoles

PS Gribanov, AN Philippova, MA Topchiy, LI Minaeva… - Molecules, 2022 - mdpi.com
An efficient access to the novel 5-(het) arylamino-1, 2, 3-triazole derivatives has been
developed. The method is based on Buchwald–Hartwig cross-coupling reaction of 5-Amino …

Cobalt‐Copper Ferrite Nanoparticles Catalyzed Click Reaction at Room‐Temperature: Green Access to 1, 2, 3‐Triazole Derivatives

F Matloubi Moghaddam, R Pourkaveh… - …, 2018 - Wiley Online Library
A typical Cobalt‐Copper ferrite nanoparticles (CoCuFe2O4) was used as a catalyst for one‐
pot [3+ 2] cycloaddition of alkyl azides with alkynes at room temperature in green media …

[HTML][HTML] Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis

R Vroemans, Y Verhaegen, MTT Dieu… - Beilstein Journal of …, 2018 - beilstein-journals.org
A new metal-free one-pot three-component procedure towards fully substituted
triazolochromenes has been developed, starting from commercially available materials …

Synthesis and Structure Determination of 1-(4-Methoxyphenyl)-5-methyl-N'-(2-oxoindolin-3-ylidene)-1H-1,2,3-triazole-4-carbohydrazide

BM Kariuki, BF Abdel-Wahab, AA Farahat, GA El-Hiti - Molbank, 2022 - mdpi.com
A reaction of equimolar equivalents of 1-(4-methoxyphenyl)-5-methyl-1 H-1, 2, 3-triazole-4-
carbohydrazide (1) and indoline-2, 3-dione (2) in boiling ethanol for 4 h under acidic …

Synthesis of 1, 2, 3-Triazolo-fused allocolchicine analogs via intramolecular oxidative biaryl coupling

B Krasniqi, W Dehaen - Organic letters, 2019 - ACS Publications
A novel series of 1, 2, 3-triazolo-fused allocolchicine analogs is described. The strategy to
prepare these analogs involves two steps: The first step is the synthesis of 1, 2, 3-triazole …