Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …

Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-
ageing and anticancer effects,,–. For clinical doses of metformin, AMP-activated protein …

Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Diazirines are widely used in photoaffinity labeling (PAL) to trap noncovalent interactions
with biomolecules. However, design and interpretation of PAL experiments is challenging …

Activity-based protein profiling (ABPP) is a technique that uses highly selective active-site
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …

Advances in the synthesis and screening of small-molecule libraries have accelerated the
discovery of chemical probes for studying biological processes. Still, only a small fraction of …

Covering: 2010 up to 2016 Deconvoluting the mode of action of natural products and drugs
remains one of the biggest challenges in chemistry and biology today. Chemical proteomics …

Stimulator of interferon genes (STING) is a dimeric transmembrane adapter protein that
plays a key role in the human innate immune response to infection and has been …

Phenotype-based screening has emerged as an alternative route for discovering new
chemical entities toward first-in-class therapeutics. However, clarifying their mode of action …