Targeted nuclear medicine. Seek and destroy
VM Tolmachev, VI Chernov… - Russian Chemical …, 2022 - iopscience.iop.org
The targeted delivery of radionuclides to tumours holds great promise for diagnosis and
treatment of malignant neoplasms. The development of scaffold proteins has significantly …
treatment of malignant neoplasms. The development of scaffold proteins has significantly …
[HTML][HTML] Reducing the renal retention of low-to moderate-molecular-weight radiopharmaceuticals
DM Chigoho, J Bridoux, S Hernot - Current Opinion in Chemical Biology, 2021 - Elsevier
The field of nuclear imaging and therapy is rapidly progressing with the development of
targeted radiopharmaceuticals that show rapid targeting and rapid clearance with minimal …
targeted radiopharmaceuticals that show rapid targeting and rapid clearance with minimal …
Evaluation of an 131I-labeled HER2-specific single domain antibody fragment for the radiopharmaceutical therapy of HER2-expressing cancers
Y Feng, R Meshaw, D McDougald, Z Zhou, XG Zhao… - Scientific reports, 2022 - nature.com
Radiopharmaceutical therapy (RPT) is an attractive strategy for treatment of disseminated
cancers including those overexpressing the HER2 receptor including breast, ovarian and …
cancers including those overexpressing the HER2 receptor including breast, ovarian and …
ImmunoPET imaging of multiple myeloma with [68Ga]Ga-NOTA-Nb1053
C Wang, Y Chen, YN Hou, Q Liu, D Zhang… - European Journal of …, 2021 - Springer
Purpose Multiple myeloma (MM) remains incurable and its diagnosis relies heavily on bone
marrow aspiration and biopsy. CD38 is a glycoprotein highly specific for MM. Antibody …
marrow aspiration and biopsy. CD38 is a glycoprotein highly specific for MM. Antibody …
Antibodies as Biosensors' Key Components: State-of-the-Art in Russia 2020–2021
N Rudenko, K Fursova, A Shepelyakovskaya… - Sensors, 2021 - mdpi.com
The recognition of biomolecules is crucial in key areas such as the timely diagnosis of
somatic and infectious diseases, food quality control, and environmental monitoring. This …
somatic and infectious diseases, food quality control, and environmental monitoring. This …
Comparative Preclinical Evaluation of Peptide-Based Chelators for the Labeling of DARPin G3 with 99mTc for Radionuclide Imaging of HER2 Expression in Cancer
M Larkina, E Plotnikov, E Bezverkhniaia… - International Journal of …, 2022 - mdpi.com
Non-invasive radionuclide imaging of human epidermal growth factor receptor type 2
(HER2) expression in breast, gastroesophageal, and ovarian cancers may stratify patients …
(HER2) expression in breast, gastroesophageal, and ovarian cancers may stratify patients …
Visualization of epithelial cell adhesion molecule-expressing renal cell carcinoma xenografts using designed ankyrin repeat protein Ec1 labelled with 99mTc and 125I
V Tolmachev, V Bodenko, A Orlova… - Oncology …, 2022 - spandidos-publications.com
The upregulation of epithelial cell adhesion molecule (EpCAM) expression, found in a
substantial fraction of renal cell carcinomas (RCCs), renders it a potential molecular target …
substantial fraction of renal cell carcinomas (RCCs), renders it a potential molecular target …
Sortase-Mediated Site-Specific Conjugation and 89Zr-Radiolabeling of Designed Ankyrin Repeat Proteins for PET
R Fay, I Törő, AL Schinke, B Simic… - Molecular …, 2022 - ACS Publications
Designed ankyrin repeat proteins (DARPins) are genetically engineered proteins that exhibit
high specificity and affinity toward specific targets. Here, the G3-DARPin, which binds the …
high specificity and affinity toward specific targets. Here, the G3-DARPin, which binds the …
Radionuclide molecular imaging of EpCAM expression in triple-negative breast cancer using the scaffold protein DARPin Ec1
A Vorobyeva, E Bezverkhniaia, E Konovalova… - Molecules, 2020 - mdpi.com
Efficient treatment of disseminated triple-negative breast cancer (TNBC) remains an unmet
clinical need. The epithelial cell adhesion molecule (EpCAM) is often overexpressed on the …
clinical need. The epithelial cell adhesion molecule (EpCAM) is often overexpressed on the …
Influence of the position and composition of radiometals and radioiodine labels on imaging of Epcam expression in prostate cancer model using the DARPin Ec1
SM Deyev, T Xu, Y Liu, A Schulga, E Konovalova… - Cancers, 2021 - mdpi.com
Simple Summary Metastasis-targeting therapy might improve outcomes in oligometastatic
prostate cancer. Epithelial cell adhesion molecule (EpCAM) is overexpressed in 40–60% of …
prostate cancer. Epithelial cell adhesion molecule (EpCAM) is overexpressed in 40–60% of …