Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly
the longest-living mammal. These animals should possess protective molecular adaptations …

Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Discerning the relationship between sociality and longevity would permit a deeper
understanding of how animal life history evolved. Here, we perform a phylogenetic …

Understanding aging is a grand challenge in biology. Exceptionally long-lived animals have
mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats …

Lifespan varies significantly among mammals, with more than 100‐fold difference between
the shortest and longest living species. This natural difference may uncover the evolutionary …

Much of the current research on longevity focuses on the aging process within a single
species. Several molecular players (eg IGF1 and MTOR), pharmacological compounds (eg …

Radical lifespan disparities exist in the animal kingdom. While the ocean quahog can
survive for half a millennium, the mayfly survives for less than 48 h. The evolutionary …