Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been
widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of …

Silibinin is a natural plant polyphenol with high antioxidant and anticancer properties, which
causes broad-spectrum efficacy against cancer, including cell cycle arrest and apoptosis in …

Purpose Silibinin is the most active flavonolignan constituent of Silymarin, the extract of milk
thistle seeds. In this study, we investigated the anticancer properties and molecular …

Introduction Super-paramagnetic iron oxide nanoparticles (SPIONs) are known as promising
theranostic nano-drug carriers with magnetic resonance imaging (MRI) properties. Applying …

Background Silibinin, as a chemopreventive agent, has shown anti-cancer efficacy against
different types of cancers. In the present study, we investigated the anti-cancer activities of …

Silymarin (SL) has a long history of use for the treatment of a variety of diseases, but several
limitations, such as poor bioavailability and negligible solubility, have restricted its …

Transforming growth factor (TGF)‑β1 is highly expressed in bladder transitional cell
carcinoma (TCC) and is positively associated with tumor grade. TGF‑β1 signaling promotes …

Background Rhomboid domain containing 1 (RHBDD1) plays a crucial role in
tumorigenesis. Silibinin, which is a natural extract from milk thistle, has shown anti-tumor …

Apoptotic effects of secoisolariciresinol diglucoside (SDG) in 2D and 3D cultures of SW480
cells were investigated. 40–200 μM SDG was used and IC50 values were determined for …

The demand for the development of three-dimensional (3D) cell culture models in
both/either drug screening and/or toxicology is gradually magnified. Natural Products …