Advances in Engineered Macrophages: A New Frontier in Cancer Immunotherapy

S Yang, Y Wang, J Jia, Y Fang, Y Yang, W Yuan… - Cell Death & …, 2024 - nature.com
Macrophages, as pivotal cells within the tumour microenvironment, significantly influence
the impact of and reactions to treatments for solid tumours. The rapid evolution of …

Targeted Drug Delivery: From Chemistry to Robotics at Small Scales

M Kim, JD Nicholas, J Puigmartí-Luis… - Annual Review of …, 2024 - annualreviews.org
The limited bioavailability, susceptibility to degradation, and adverse side effects of novel
drugs often hinder their effective administration. Nanoparticles, with customizable properties …

A red blood cell‐derived bionic microrobot capable of hierarchically adapting to five critical stages in systemic drug delivery

YX Zhu, HR Jia, YW Jiang, Y Guo, QY Duan… - …, 2024 - Wiley Online Library
The tumour‐targeting efficiency of systemically delivered chemodrugs largely dictates the
therapeutic outcome of anticancer treatment. Major challenges lie in the complexity of …

Field‐Directed Motion, Cargo Capture, and Closed‐Loop Controlled Navigation of Microellipsoids

HM Gauri, R Patel, NS Lombardo, MA Bevan, B Bharti - Small, 2024 - Wiley Online Library
Microrobots have the potential for diverse applications, including targeted drug delivery and
minimally invasive surgery. Despite advancements in microrobot design and actuation …

State of the Art in Actuation of Micro/Nanorobots for Biomedical Applications

A Elnaggar, S Kang, M Tian, B Han… - Small Science, 2024 - Wiley Online Library
The emergence of micro/nanorobotics stands poised to revolutionize various biomedical
applications, given its potential to offer precision, reduced invasiveness, and enhanced …

Macrophage-based microrobots for anticancer therapy: recent progress and future perspectives

VD Nguyen, JO Park, E Choi - Biomimetics, 2023 - mdpi.com
Macrophages, which are part of the mononuclear phagocytic system, possess sensory
receptors that enable them to target cancer cells. In addition, they are able to engulf large …

Hollow magnetic nanocarrier-based microrobot swarms for NIR-responsive targeted drug delivery and synergistic therapy

X Chen, Q Cao, Z Liang, L Huang… - ACS Applied Materials …, 2024 - ACS Publications
Nanocarriers are frequently used for drug delivery due to their large surface area,
biocompatibility, and photothermal effects. However, they face the problem of premature …

Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy

H Xu, D Kim, YY Zhao, C Kim, G Song, Q Hu… - Advanced …, 2024 - Wiley Online Library
Cancer treatment requires precise tumor‐specific targeting at specific sites that allows for
high‐resolution diagnostic imaging and long‐term patient‐tailorable cancer therapy; while …

Bio-Hybrid Magnetic Robots: From Bioengineering to Targeted Therapy

Q Zhang, Y Zeng, Y Zhao, X Peng, E Ren, G Liu - Bioengineering, 2024 - mdpi.com
Magnetic robots possess an innate ability to navigate through hard-to-reach cavities in the
human body, making them promising tools for diagnosing and treating diseases minimally …

Engineered Microrobots for Targeted Delivery of Bacterial Outer Membrane Vesicles (OMV) in Thrombus Therapy

Z Cong, Y Li, L Xie, Q Chen, M Tang, P Thongpon… - Small, 2024 - Wiley Online Library
In the realm of thrombosis treatment, bioengineered outer membrane vesicles (OMVs) offer
a novel and promising approach, as they have rich content of bacterial‐derived components …