During the early development of Placentalia, a distinctive projection emerges at the posterior
embryonic–extraembryonic interface of the conceptus; its fingerlike shape presages …

Current dogma is that mouse primordial germ cells (PGCs) segregate within the allantois, or
source of the umbilical cord, and translocate to the gonads, differentiating there into sperm …

In mice and humans the X-chromosomal porcupine homolog (Porcn) gene is required for the
acylation and secretion of all 19 Wnt ligands and thus represents a bottleneck for all Wnt …

Mesoderm arises at gastrulation and contributes to both the mouse embryo proper and its
extra‐embryonic membranes. Two‐photon live imaging of embryos bearing a keratin …

Hypoblast/visceral endoderm assists in amniote nutrition, axial positioning and formation of
the gut. Here, we provide evidence, currently limited to humans and non-human primates …

Although many fetal birth defects, particularly those of the body wall and gut, are associated
with abnormalities of the umbilical cord, the developmental relationship between these …

The developmental relationship between the posterior embryonic and extraembryonic
regions of the mammalian gastrula is poorly understood. Although many different cell types …

In Placentalia, the fetus depends upon an organized vascular connection with its mother for
survival and development. Yet, this connection was, until recently, obscure. Here, we …

Interferon-induced transmembrane protein 3 (IFITM3; FRAGILIS; MIL-1) is part of a larger
family of important small interferon-induced transmembrane genes and proteins involved in …

Background: PRDM1 is a transcriptional repressor that contributes to primordial germ cell
(PGC) development. During early gastrulation, epiblast‐derived PRDM1 is thought to be …