Olfactory receptors in non-chemosensory organs: the nervous system in health and disease

I Ferrer, P Garcia-Esparcia, M Carmona… - Frontiers in aging …, 2016 - frontiersin.org
Olfactory receptors (ORs) and down-stream functional signaling molecules adenylyl cyclase
3 (AC3), olfactory G protein α subunit (Gαolf), OR transporters receptor transporter proteins 1 …

The state of the art of odorant receptor deorphanization: a report from the orphanage

Z Peterlin, S Firestein, ME Rogers - Journal of General Physiology, 2014 - rupress.org
The odorant receptors (ORs) provide our main gateway to sensing the world of volatile
chemicals. This involves a complex encoding process in which multiple ORs, each of which …

Mammalian olfactory receptors

J Fleischer, H Breer, J Strotmann - Frontiers in Cellular Neuroscience, 2009 - frontiersin.org
Perception of chemical stimuli from the environment is essential to most animals;
accordingly, they are equipped with a complex olfactory system capable of receiving a …

Functional genomics reveals dysregulation of cortical olfactory receptors in Parkinson disease: novel putative chemoreceptors in the human brain

P Garcia-Esparcia, A Schlüter… - … of Neuropathology & …, 2013 - academic.oup.com
Parkinson disease (PD) is no longer considered a complex motor disorder but rather a
systemic disease with variable nonmotor deficits that may include impaired olfaction …

Insights into the binding of Phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor

X Biarnés, A Marchiori, A Giorgetti, C Lanzara… - PloS one, 2010 - journals.plos.org
Humans' bitter taste perception is mediated by the hTAS2R subfamily of the G protein-
coupled membrane receptors (GPCRs). Structural information on these receptors is currently …

Olfactory receptor based piezoelectric biosensors for detection of alcohols related to food safety applications

S Sankaran, S Panigrahi, S Mallik - Sensors and Actuators B: Chemical, 2011 - Elsevier
Our major goal in developing intelligent quality sensors is to detect bacterial pathogens such
as Salmonella in the packaged beef. Olfactory sensing of specific volatile organic …

GOMoDo: a GPCRs online modeling and docking webserver

M Sandal, TP Duy, M Cona, H Zung, P Carloni… - PloS one, 2013 - journals.plos.org
G-protein coupled receptors (GPCRs) are a superfamily of cell signaling membrane proteins
that include> 750 members in the human genome alone. They are the largest family of drug …

Prediction of a ligand‐binding niche within a human olfactory receptor by combining site‐directed mutagenesis with dynamic homology modeling

L Gelis, S Wolf, H Hatt, EM Neuhaus… - Angewandte Chemie …, 2012 - Wiley Online Library
The mammalian olfactory system comprises a large family of G protein-coupled receptors
(GPCRs) to detect and discriminate numerous volatile ligands. More than 350 human genes …

The mouse eugenol odorant receptor: structural and functional plasticity of a broadly tuned odorant binding pocket

O Baud, S Etter, M Spreafico, L Bordoli, T Schwede… - Biochemistry, 2011 - ACS Publications
Molecular interactions of odorants with their olfactory receptors (ORs) are of central
importance for the ability of the mammalian olfactory system to detect and discriminate a vast …

Olfactory receptor signaling

G Antunes, FMS de Souza - Methods in cell biology, 2016 - Elsevier
The guanine nucleotide protein (G protein)-coupled receptors (GPCRs) superfamily
represents the largest class of membrane protein in the human genome. More than a half of …