The use of metal catalysts to produce and control the reactivity of carbenes has long offered
a powerful approach to organic synthesis; however, difluorocarbene transfer catalysed by …

Our society is pursuing chemically recyclable polymers to accelerate the green revolution in
plastics. Here, we develop a recyclable polyester library from the alternating …

Cyclopropanes are key features in many preclinical, clinical, and commercial drugs, as well
as natural products. The most prolific technique for their synthesis is the metal-catalyzed …

Cyclopropanes are common building blocks in pharmaceuticals, agrochemicals, and
organic materials. The most general methods for the synthesis of chiral cyclopropanes are …

Carbonyls and alkenes are versatile functional groups, whose reactivities are cornerstones
of organic synthesis. The selective combination of two carbonyls to form an alkene—a …

Biosynthesis is an environmentally benign and renewable approach that can be used to
produce a broad range of natural and, in some cases, new-to-nature products. However …

Cyclopropanes are desirable structural motifs with valuable applications in drug discovery
and beyond. Established alkene cyclopropanation methods give rise to cyclopropanes with …

Although a ripe old discipline by now, carbene chemistry continues to flourish as both
theorists and experimentalists have shown sustained interest in this area of research. While …

The catalytic asymmetric cyclopropanation reaction of alkenes with diazo compounds is a
direct and powerful method to construct chiral cyclopropanes that are essential to drug …

Transition metal‐catalyzed carbene transfer reactions have a century‐old history in organic
chemistry and are a primary method for the synthesis of cyclopropanes. Much of the work in …