Large epidemiological and health impact assessment studies at the global scale, such as
the Global Burden of Disease project, indicate that chronic non-communicable diseases …

Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

Early life is an important window of opportunity to improve health across the full lifecycle. An
accumulating body of evidence suggests that exposure to adverse stressors during early life …

Elucidating the mechanisms that sustain asthmatic inflammation is critical for precision
therapies. We found that interleukin-6-and STAT3 transcription factor-dependent …

Background Exposure to air pollution during the first 1000 days of life (from conception to the
2 nd year of life) might be of particular relevance for long-term child health. Changes in …

Sedentary lifestyle and consumption of high-calorie foods have caused a relentless increase
of overweight and obesity prevalence at all ages. Its presently epidemic proportion is …

Background Emerging research suggested an association of early-life particulate air
pollution exposure with development of asthma in childhood. However, the potentially …

Investigation of gene‐environment interactions (GxE) may provide important insights into the
gene regulatory framework in response to environmental factors of relevance for childhood …

Exposure to airborne particulate matter (PM) has been associated with detrimental health
effects. DNA methylation represents the most well-studied epigenetic factor among the …

Asthma is a complex multifactorial and heterogeneous respiratory disease. Although
genetics is a strong risk factor of asthma, external and internal exposures and their …