Simple Summary Environmental light exposure is an important factor for human health that
impacts the biological clock of organisms. Melatonin usually serves as a chemical …

The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation
of blood volume and blood pressure. Dysfunction of this system is connected with …

Exchange proteins directly activated by cAMP (Epac) proteins are implicated in a wide range
of cellular functions including oxidative stress and cell survival. Mitochondrial-dependent …

The evolutionarily conserved soluble adenylyl cyclase (sAC, ADCY10) mediates cAMP
signaling exclusively in intracellular compartments. Because sAC activity is sensitive to local …

The mineralocorticoid aldosterone regulates electrolyte and blood volume homeostasis, but
it also adversely modulates the structure and function of the chronically failing heart, through …

Air pollution is a major environmental threat and each year about 7 million people reported
to die as a result of air pollution. Consequently, exposure to air pollution is linked to …

Mitochondria produce the bulk of the ATP in most cells, including brain cells. Regulating this
complex machinery to match the energetic needs of the cell is a complicated process that we …

Cytosolic cAMP signalling in live cells has been extensively investigated in the past, while
only in the last decade the existence of an intramitochondrial autonomous cAMP …

The compartmentation of signaling processes is accomplished by the assembly of protein
complexes called signalosomes. These signaling platforms colocalize enzymes, substrates …

Type 2 taste receptors (TAS2R) are G protein–coupled receptors first described in the
gustatory system, but have also been shown to have extraoral localizations, including airway …