Transdermal drug delivery systems (TDDS), commonly refered to as" patches", present a
nonintrusive technique to provide medication without the need for invasive procedures …

Bioavailability assessment in the development phase of a drug product is vital to reveal the
disadvantageous properties of the substance and the possible technological interventions …

This study aims to shed light on the relationship between drug content and adhesive
properties in drug-in-adhesive transdermal patch, and to elucidate molecular mechanisms …

With the developing manufacturing technologies, the use of 3D printers in microneedle
production is becoming widespread. Hydrogel-forming microneedles (HFMs), a variant of …

Background Although the quality by design (QbD) approach is widely used to develop
pharmaceutical products and to consistently ensure and improve product quality, studies on …

The application of pressure-sensitive adhesives (PSAs) in transdermal drug delivery
systems (TDDSs) is limited. Insufficient cohesion in TDDS can lead to cold flow, patch …

In transdermal patches, pressure-sensitive adhesives (PSAs) are considered the most
critical excipients due to their ability to provide adhesion and act as a drug reservoir …

Improving the adhesion and tack of pressure-sensitive adhesives (PSAs) remains an
ongoing challenge. Polyureas often have stronger hydrogen bonding relative to, the more …

The skin offers an available and advantageous site for the administration of medica‐ments.
For millennia, individuals have used substances on the skin for remedial therapy, and in the …

The objective of this study was to develop a simpler and more practical quantitative
evaluation method of cold flow (CF) in transdermal drug delivery systems (TDDSs). CF was …