Cocrystals are an emerging class of crystalline materials composed of two or more different
molecules in the same crystal lattice that are physically connected by non-ionic and non …

Stability is an essential quality attribute of any pharmaceutical formulation. Poor stability can
change the color and physical appearance of a drug, directly impacting the patient's …

Cocrystals are long known yet recently applied molecular entities. In the past decade, a
significant potential has been demonstrated by these novel solids in terms of modifying the …

The ambient humidity varies with seasons and geographical altitude across the regions. A
change in relative humidity during processing, storage, and transportation can cause …

Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

Favipiravir (FPV) is used in the treatment of viral influenza, but it faces challenges due to its
moderate solubility and poor tabletability. As an oral drug, it is necessary to develop a drug …

Pirfenidone (PFD) is the first pharmacological agent approved by the US Food and Drug
Administration (FDA) in 2014 for the treatment of idiopathic pulmonary fibrosis (IPF). The …

Phase transformation of an active pharmaceutical ingredient in the solid state can influence
the physicochemical properties and consequently drug product performance. The neat …

The stability of theophylline cocrystals composed of acidic (glutaric acid), basic
(isonicotinamide), or neutral (benzamide) coformers was evaluated in the presence of …

Optimization of manufacturing processes based on scientific evidence is important in the
quality control of active pharmaceutical ingredients (APIs) and drug products, particularly …