[HTML][HTML] Generative models of morphogenesis in developmental biology

NR Stillman, R Mayor - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Understanding the mechanism by which cells coordinate their differentiation and migration
is critical to our understanding of many fundamental processes such as wound healing …

Oncoimmunology meets organs-on-chip

F Mattei, S Andreone, A Mencattini… - Frontiers in Molecular …, 2021 - frontiersin.org
Oncoimmunology represents a biomedical research discipline coined to study the roles of
immune system in cancer progression with the aim of discovering novel strategies to arm it …

A Clinically Feasible Diagnostic Typing of Breast Cancer Built on a Homogeneous Electrochemical Biosensor for Simultaneous Multiplex Detection

Y Zhang, WH Ma, N Li, M Yang, C Hou… - Analytical …, 2024 - ACS Publications
Simultaneous detection of multiple tumor markers is of great significance for an accurate
diagnosis and early treatment of cancer. Electrochemical homogeneous biosensing …

A roadmap for translational cancer glycoimmunology at single cell resolution

A Peixoto, A Miranda, LL Santos, JA Ferreira - Journal of Experimental & …, 2022 - Springer
Cancer cells can evade immune responses by exploiting inhibitory immune checkpoints.
Immune checkpoint inhibitor (ICI) therapies based on anti-CTLA-4 and anti-PD-1/PD-L1 …

Machine learning approach for recognition and morphological analysis of isolated astrocytes in phase contrast microscopy

EV Yakovlev, IV Simkin, AA Shirokova, NA Kolotieva… - Scientific Reports, 2024 - nature.com
Astrocytes are glycolytically active cells in the central nervous system playing a crucial role
in various brain processes from homeostasis to neurotransmission. Astrocytes possess a …

Single-cell classification based on label-free high-resolution optical data of cell adhesion kinetics

KD Kovacs, B Beres, N Kanyo, B Szabó, B Peter… - Scientific Reports, 2024 - nature.com
Selecting and isolating various cell types is a critical procedure in many applications,
including immune therapy, regenerative medicine, and cancer research. Usually, these …

Exploiting spectral information in Opto-Electronic Tweezers for cell classification and drug response evaluation

J Filippi, D Di Giuseppe, P Casti, A Mencattini… - Sensors and Actuators B …, 2022 - Elsevier
Cell responses to varying electric fields can reveal insights on cell biology with important
implications for pharmaceutical and basic research. In this work, we exploit spectral …

Cell Electrokinetic Fingerprint: A Novel Approach Based on Optically Induced Dielectrophoresis (ODEP) for In‐Flow Identification of Single Cells

J Filippi, P Casti, G Antonelli, M Murdocca… - Small …, 2024 - Wiley Online Library
A novel optically induced dielectrophoresis (ODEP) system that can operate under flow
conditions is designed for automatic trapping of cells and subsequent induction of 2D multi …

Domain adaptation to enhance (2+ 1) D CNN dynamic analysis of cell collective behavior in time-lapse microscopy videos

M D'Orazio, D Pastore, A Mencattini, J Filippi… - Neural Computing and …, 2024 - Springer
In recent years, 2D CNNs have excelled in analyzing single-frame video sequences,
prompting the evolution of standard architectures toward full 3D CNNs. This transition, while …

[HTML][HTML] Cells in the 3D biomatrix on-chip: better mimicking the real micro-physiological system

M D'Orazio, J Filippi, G Antonelli, G Curci, P Casti… - Next Materials, 2024 - Elsevier
Recent advances in microfluidic technology and biomaterial science have augmented the
use of organ-on-chip (OoC) technology to closely mimic the human pathophysiology. Thus, it …