Centromeres are the eukaryotic chromosomal sites at which the kinetochore forms and
attaches to spindle microtubules to orchestrate chromosomal segregation in mitosis and …

Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed …

Background Centromeres are essential for chromosome segregation, yet their DNA
sequences evolve rapidly. In most animals and plants that have been studied, centromeres …

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Most of the human genome consists of non-protein-coding DNA. Recently, progress has
been made in annotating these non-coding regions through the interpretation of functional …

The histone H3 variant CenH3, called CENP-A in humans, is central in centromeric
chromatin to ensure proper chromosome segregation. In the absence of an underlying DNA …

The basic element for chromosome inheritance, the centromere, is epigenetically
determined in mammals. The prime candidate for specifying centromere identity is the array …

Centromeres direct chromosomal inheritance by nucleating assembly of the kinetochore, a
large multiprotein complex required for microtubule attachment during mitosis. Centromere …

Histone lysine methylation has been shown to index silenced chromatin regions at, for
example, pericentric heterochromatin or of the inactive X chromosome. Here, we examined …

Satellite DNAs are now regarded as powerful and active contributors to genomic and
chromosomal evolution. Paired with mobile transposable elements, these repetitive …