Radioactive transition metals for imaging and therapy

E Boros, AB Packard - Chemical reviews, 2018 - ACS Publications
Nuclear medicine is composed of two complementary areas, imaging and therapy. Positron
emission tomography (PET) and single-photon imaging, including single-photon emission …

Radionuclide candidates for β+ γ coincidence PET: an overview

M Sitarz, JP Cussonneau, T Matulewicz… - Applied Radiation and …, 2020 - Elsevier
Following the advancement of the Positron Emission Tomography (PET), a novel technique
emerged which takes advantage of the gamma quanta emitted, in some cases, after the β+ …

PET radiometals for antibody labeling

E Aluicio‐Sarduy, PA Ellison… - Journal of Labelled …, 2018 - Wiley Online Library
Recent advances in molecular characterization of tumors have made possible the
emergence of new types of cancer therapies where traditional cytotoxic drugs and …

Cyclotron production and radiochemical separation of 55Co and 58mCo from 54Fe, 58Ni and 57Fe targets

HF Valdovinos, R Hernandez, S Graves… - Applied Radiation and …, 2017 - Elsevier
This work presents the production with a cyclotron of the positron emitter 55 Co via the 54 Fe
(d, n) and 58 Ni (p, α) reactions and the Auger electron emitter 58m Co via the 57 Fe (d, n) …

Production, purification, and applications of a potential theranostic pair: cobalt-55 and cobalt-58m

KE Barrett, HA Houson, W Lin, SE Lapi, JW Engle - Diagnostics, 2021 - mdpi.com
The emerging success of [68Ga/177Lu] Ga/Lu-DOTATATE as a theranostic pair has spurred
interest in other isotopes as potential theranostic combinations. Here, we review cobalt-55 …

Expanding PET-applications in life sciences with positron-emitters beyond fluorine-18

HH Coenen, J Ermert - Nuclear medicine and biology, 2021 - Elsevier
Abstract Positron-emission-tomography (PET) has become an indispensable diagnostic tool
in modern nuclear medicine. Its outstanding molecular imaging features allow repetitive …

High contrast PET imaging of GRPR expression in prostate cancer using cobalt‐labeled Bombesin antagonist RM26

B Mitran, H Thisgaard, U Rosenström… - Contrast Media & …, 2017 - Wiley Online Library
High gastrin releasing peptide receptor (GRPR) expression is associated with numerous
cancers including prostate and breast cancer. The aim of the current study was to develop a …

Design and synthesis of a new bifunctional chelating agent: Application for Al 18F/177Lu complexation

W Laurène, L Raúl, S Katalin, F Céline, K Gilles… - Journal of Inorganic …, 2023 - Elsevier
Theranostic and personalized medicine are blooming strategies to improve oncologic
patients' health care and facilitate early treatment. While 18 F-radiochemistry for theranostic …

The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule

J Garousi, KG Andersson, JH Dam, BB Olsen… - Scientific Reports, 2017 - nature.com
Several anti-cancer therapies target the epidermal growth factor receptor (EGFR).
Radionuclide imaging of EGFR expression in tumours may aid in selection of optimal cancer …

Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26

B Mitran, H Thisgaard, S Rinne, JH Dam, F Azami… - Scientific Reports, 2019 - nature.com
Gastrin-releasing peptide receptors (GRPRs) are promising targets in oligometastatic
prostate cancer. We have recently used 55Co (T1/2= 17.5 h) as a label for next day PET …