Mutations in the transcriptional regulator, Aire, cause APECED, a polyglandular autoimmune
disease with monogenic transmission. Animal models of APECED have revealed that Aire …

The INhibitor of Growth (ING) family of type II tumour suppressors are encoded by five genes
in mammals (ING1–ING5), most of which encode multiple isoforms via splicing, and all of …

The monocytic leukemia zinc finger protein MOZ and the related factor MORF form
tetrameric complexes with ING5 (inhibitor of growth 5), EAF6 (Esa1-associated factor 6 …

A major challenge in chromatin biology is to understand the mechanisms by which
chromatin is remodeled into active or inactive states as required during development and …

Aberrations in chromatin dynamics play a fundamental role in tumorigenesis, yet relatively
little is known of the molecular mechanisms linking histone lysine methylation to neoplastic …

Gene expression is regulated by a number of interrelated posttranslational modifications of
histones, including citrullination. For example, peptidylarginine deminase 4 (PAD4) converts …

Histone acetylation is a hallmark for gene transcription. As a histone acetyltransferase, MOZ
(monocytic leukemia zinc finger protein) is important for HOX gene expression as well as …

Epigenetic regulation of gene transcription relies on an array of recurring structural domains
that have evolved to recognize post-translational modifications on histones. The roles of …

The Inhibitor of Growth (ING) tumor suppressors are implicated in oncogenesis, control of
DNA damage repair, cellular senescence and apoptosis. All members of the ING family …

The NF-κB family mediates immune and inflammatory responses. In many cancers, NF-κB is
constitutively activated and induces the expression of genes that facilitate tumorigenesis …