Presynaptic terminals are specialized compartments of neurons responsible for converting
electrical signals into secreted chemicals. This self-renewing process of chemical synaptic …

Central nerve terminals release neurotransmitter in response to a wide variety of stimuli.
Because maintenance of neurotransmitter release is dependent on the continual supply of …

The existence of neuron-specific endocytic protein isoforms raises questions about their
importance for specialized neuronal functions. Dynamin, a GTPase implicated in the fission …

Dynamin mediates fission of vesicles from the plasma membrane during endocytosis.
Typically, dynamin is recruited from the cytosol to endocytic sites, requiring seconds to tens …

Clathrin-mediated vesicle recycling in synapses is maintained by a unique set of endocytic
proteins and interactions. We show that endophilin localizes in the vesicle pool at rest and in …

Synaptic vesicles (SVs) are retrieved by more than one mode in central nerve terminals.
During mild stimulation, the dominant SV retrieval pathway is classical clathrin-mediated …

Members of the Bin/amphiphysin/Rvs (BAR) domain protein superfamily are involved in
membrane remodeling in various cellular pathways ranging from endocytic vesicle and T …

Synaptic vesicle (SV) endocytosis is a critical and well-regulated process for the
maintenance of neurotransmission. We previously reported that synaptotagmin-11 (Syt11) …

Dynamin is a 100 kDa GTPase that organizes into helical assemblies at the base of nascent
clathrin-coated vesicles. Formation of these oligomers stimulates the intrinsic GTPase …

Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Fast
Endophilin-mediated endocytosis, FEME, is not constitutively active but triggered upon …