The biology and functional importance of MAIT cells
DI Godfrey, HF Koay, J McCluskey, NA Gherardin - Nature immunology, 2019 - nature.com
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
Klebsiella pneumoniae: going on the offense with a strong defense
MK Paczosa, J Mecsas - Microbiology and molecular biology …, 2016 - Am Soc Microbiol
Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …
Mucosal-associated invariant T cells and disease
A Toubal, I Nel, S Lotersztajn, A Lehuen - Nature Reviews Immunology, 2019 - nature.com
Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate
and adaptive immunity. They are activated by conserved bacterial ligands derived from …
and adaptive immunity. They are activated by conserved bacterial ligands derived from …
Mining the microbiota for microbial and metabolite-based immunotherapies
Trillions of microorganisms transit through and reside in the mammalian gastrointestinal tract
each day, collectively producing thousands of small molecules and metabolites with local …
each day, collectively producing thousands of small molecules and metabolites with local …
MAIT cells are activated during human viral infections
B Van Wilgenburg, I Scherwitzl, EC Hutchinson… - Nature …, 2016 - nature.com
Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human …
[HTML][HTML] Hallmarks of tissue-resident lymphocytes
X Fan, AY Rudensky - Cell, 2016 - cell.com
Although they are classically viewed as continuously recirculating through the lymphoid
organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most …
organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most …
MAIT cell development and functions: the microbial connection
F Legoux, M Salou, O Lantz - Immunity, 2020 - cell.com
Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved T cell subset,
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …
which reacts to most bacteria through T cell receptor (TCR)-mediated recognition of …
CD161++CD8+ T cells, including the MAIT cell subset, are specifically activated by IL‐12+IL‐18 in a TCR‐independent manner
CD 161++ CD 8+ T cells represent a novel subset that is dominated in adult peripheral
blood by mucosal‐associated invariant T (MAIT) cells, as defined by the expression of a …
blood by mucosal‐associated invariant T (MAIT) cells, as defined by the expression of a …
[HTML][HTML] MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
A Kurioka, JE Ussher, C Cosgrove, C Clough… - Mucosal …, 2015 - Elsevier
Mucosal-associated invariant T (MAIT) cells are an innate-like T-cell population restricted by
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …
the non-polymorphic, major histocompatibility complex class I-related protein 1, MR1. MAIT …
TCR-or cytokine-activated CD8+ mucosal-associated invariant T cells are rapid polyfunctional effectors that can coordinate immune responses
R Lamichhane, M Schneider, SM de la Harpe… - Cell reports, 2019 - cell.com
Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin …
(TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin …